Abstract
Intensive chemotherapy given in early chronic phase of chronic myelogenous leukemia (CML) has resulted in high numbers of circulating Philadelphia (Ph) chromosome-negative hematopoietic progenitor cells (HPC). We have autografted 30 consecutive patients with CML in chronic phase with HPC collected in this way to facilitate restoration of Ph-negative hematopoiesis in bone marrow after high-dose therapy. Hematopoietic recovery to greater than 0.5 x 109/L neutrophils and to greater than 25 x 109/L platelets occurred in all patients, a median of 13 (range, 9 to 32) days and 16 (range, 6 to 106) days postautograft, respectively. Regenerating marrow cells were Ph-negative in 16 (53%) patients and greater than 66% Ph-negative in 10 (33%) patients. Twenty-eight patients are alive 6 to 76 months (median, 24 months) after autografting. Three patients have developed blast crisis from which 2 have died. Eight patients are in complete cytogenetic remission at a median of 20 (range, 6 to 44) months with a median ratio BCR-ABL/ABL of 0.002 (range,
| Original language | English |
|---|---|
| Pages (from-to) | 1534-1539 |
| Number of pages | 6 |
| Journal | Blood |
| Volume | 93 |
| Issue number | 5 |
| Publication status | Published - Mar 1 1999 |
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ASJC Scopus subject areas
- Hematology
Cite this
Autografting with Philadelphia chromosome-negative mobilized hematopoietic progenitor cells in chronic myelogenous leukemia. / Carella, Angelo M.; Lerma, Enrica; Corsetti, Maria T.; Dejana, Anna; Basta, Palmina; Vassallo, Franca; Abate, Monica; Soracco, Monica; Benvenuto, Federica; Figari, Osvaldo; Podestà, Marina; Piaggio, Giovanna; Ferrara, Raimondo; Sessarego, Mario; Parodi, Caterina; Pizzuti, Michele; Rubagotti, Alessandra; Occhini, Domenico; Frassoni, Francesco.
In: Blood, Vol. 93, No. 5, 01.03.1999, p. 1534-1539.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Autografting with Philadelphia chromosome-negative mobilized hematopoietic progenitor cells in chronic myelogenous leukemia
AU - Carella, Angelo M.
AU - Lerma, Enrica
AU - Corsetti, Maria T.
AU - Dejana, Anna
AU - Basta, Palmina
AU - Vassallo, Franca
AU - Abate, Monica
AU - Soracco, Monica
AU - Benvenuto, Federica
AU - Figari, Osvaldo
AU - Podestà, Marina
AU - Piaggio, Giovanna
AU - Ferrara, Raimondo
AU - Sessarego, Mario
AU - Parodi, Caterina
AU - Pizzuti, Michele
AU - Rubagotti, Alessandra
AU - Occhini, Domenico
AU - Frassoni, Francesco
PY - 1999/3/1
Y1 - 1999/3/1
N2 - Intensive chemotherapy given in early chronic phase of chronic myelogenous leukemia (CML) has resulted in high numbers of circulating Philadelphia (Ph) chromosome-negative hematopoietic progenitor cells (HPC). We have autografted 30 consecutive patients with CML in chronic phase with HPC collected in this way to facilitate restoration of Ph-negative hematopoiesis in bone marrow after high-dose therapy. Hematopoietic recovery to greater than 0.5 x 109/L neutrophils and to greater than 25 x 109/L platelets occurred in all patients, a median of 13 (range, 9 to 32) days and 16 (range, 6 to 106) days postautograft, respectively. Regenerating marrow cells were Ph-negative in 16 (53%) patients and greater than 66% Ph-negative in 10 (33%) patients. Twenty-eight patients are alive 6 to 76 months (median, 24 months) after autografting. Three patients have developed blast crisis from which 2 have died. Eight patients are in complete cytogenetic remission at a median of 20 (range, 6 to 44) months with a median ratio BCR-ABL/ABL of 0.002 (range,
AB - Intensive chemotherapy given in early chronic phase of chronic myelogenous leukemia (CML) has resulted in high numbers of circulating Philadelphia (Ph) chromosome-negative hematopoietic progenitor cells (HPC). We have autografted 30 consecutive patients with CML in chronic phase with HPC collected in this way to facilitate restoration of Ph-negative hematopoiesis in bone marrow after high-dose therapy. Hematopoietic recovery to greater than 0.5 x 109/L neutrophils and to greater than 25 x 109/L platelets occurred in all patients, a median of 13 (range, 9 to 32) days and 16 (range, 6 to 106) days postautograft, respectively. Regenerating marrow cells were Ph-negative in 16 (53%) patients and greater than 66% Ph-negative in 10 (33%) patients. Twenty-eight patients are alive 6 to 76 months (median, 24 months) after autografting. Three patients have developed blast crisis from which 2 have died. Eight patients are in complete cytogenetic remission at a median of 20 (range, 6 to 44) months with a median ratio BCR-ABL/ABL of 0.002 (range,
UR - http://www.scopus.com/inward/record.url?scp=0033106286&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033106286&partnerID=8YFLogxK
M3 - Article
C2 - 10029581
AN - SCOPUS:0033106286
VL - 93
SP - 1534
EP - 1539
JO - Blood
JF - Blood
SN - 0006-4971
IS - 5
ER -