Autografting with Philadelphia chromosome-negative mobilized hematopoietic progenitor cells in chronic myelogenous leukemia

Angelo M. Carella, Enrica Lerma, Maria T. Corsetti, Anna Dejana, Palmina Basta, Franca Vassallo, Monica Abate, Monica Soracco, Federica Benvenuto, Osvaldo Figari, Marina Podestà, Giovanna Piaggio, Raimondo Ferrara, Mario Sessarego, Caterina Parodi, Michele Pizzuti, Alessandra Rubagotti, Domenico Occhini, Francesco Frassoni

Research output: Contribution to journalArticle

Abstract

Intensive chemotherapy given in early chronic phase of chronic myelogenous leukemia (CML) has resulted in high numbers of circulating Philadelphia (Ph) chromosome-negative hematopoietic progenitor cells (HPC). We have autografted 30 consecutive patients with CML in chronic phase with HPC collected in this way to facilitate restoration of Ph-negative hematopoiesis in bone marrow after high-dose therapy. Hematopoietic recovery to greater than 0.5 x 109/L neutrophils and to greater than 25 x 109/L platelets occurred in all patients, a median of 13 (range, 9 to 32) days and 16 (range, 6 to 106) days postautograft, respectively. Regenerating marrow cells were Ph-negative in 16 (53%) patients and greater than 66% Ph-negative in 10 (33%) patients. Twenty-eight patients are alive 6 to 76 months (median, 24 months) after autografting. Three patients have developed blast crisis from which 2 have died. Eight patients are in complete cytogenetic remission at a median of 20 (range, 6 to 44) months with a median ratio BCR-ABL/ABL of 0.002 (range,

Original languageEnglish
Pages (from-to)1534-1539
Number of pages6
JournalBlood
Volume93
Issue number5
Publication statusPublished - Mar 1 1999

ASJC Scopus subject areas

  • Hematology

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    Carella, A. M., Lerma, E., Corsetti, M. T., Dejana, A., Basta, P., Vassallo, F., Abate, M., Soracco, M., Benvenuto, F., Figari, O., Podestà, M., Piaggio, G., Ferrara, R., Sessarego, M., Parodi, C., Pizzuti, M., Rubagotti, A., Occhini, D., & Frassoni, F. (1999). Autografting with Philadelphia chromosome-negative mobilized hematopoietic progenitor cells in chronic myelogenous leukemia. Blood, 93(5), 1534-1539.