Abstract
Diabetes insipidus is a disease in which large volumes of dilute urine (polyuria) are excreted due to vasopressin (AVP) deficiency [central diabetes insipidus (CDI)] or to AVP resistance (nephrogenic diabetes insipidus). In the majority of patients, the occurrence of CDI is related to the destruction or degeneration of neurons of the hypothalamic supraoptic and paraventricular nuclei. The most common and well recognized causes include local inflammatory or autoimmune diseases, vascular disorders, Langerhans cell histiocytosis (LCH), sarcoidosis, tumors such as germinoma/craniopharyngioma or metastases, traumatic brain injuries, intracranial surgery, and midline cerebral and cranial malformations. Here we have the opportunity to describe an unusual case of female patient who developed autoimmune CDI following ureaplasma urealyticum infection and to review the literature on this uncommon feature. Moreover, we also discussed the potential mechanisms by which ureaplasma urealyticum might favor the development of autoimmune CDI.
| Original language | English |
|---|---|
| Pages (from-to) | 554-558 |
| Number of pages | 5 |
| Journal | Archives of endocrinology and metabolism |
| Volume | 59 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 1 2015 |
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ASJC Scopus subject areas
- Medicine(all)
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Autoimmune central diabetes insipidus in a patient with ureaplasma urealyticum infection and review on new triggers of immune response. / Murdaca, Giuseppe; Russo, Rodolfo; Spanò, Francesca; Ferone, Diego; Albertelli, Manuela; Schenone, Angelo; Contatore, Miriam; Guastalla, Andrea; De Bellis, Annamaria; Garibotto, Giacomo; Puppo, Francesco.
In: Archives of endocrinology and metabolism, Vol. 59, No. 6, 01.12.2015, p. 554-558.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Autoimmune central diabetes insipidus in a patient with ureaplasma urealyticum infection and review on new triggers of immune response
AU - Murdaca, Giuseppe
AU - Russo, Rodolfo
AU - Spanò, Francesca
AU - Ferone, Diego
AU - Albertelli, Manuela
AU - Schenone, Angelo
AU - Contatore, Miriam
AU - Guastalla, Andrea
AU - De Bellis, Annamaria
AU - Garibotto, Giacomo
AU - Puppo, Francesco
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Diabetes insipidus is a disease in which large volumes of dilute urine (polyuria) are excreted due to vasopressin (AVP) deficiency [central diabetes insipidus (CDI)] or to AVP resistance (nephrogenic diabetes insipidus). In the majority of patients, the occurrence of CDI is related to the destruction or degeneration of neurons of the hypothalamic supraoptic and paraventricular nuclei. The most common and well recognized causes include local inflammatory or autoimmune diseases, vascular disorders, Langerhans cell histiocytosis (LCH), sarcoidosis, tumors such as germinoma/craniopharyngioma or metastases, traumatic brain injuries, intracranial surgery, and midline cerebral and cranial malformations. Here we have the opportunity to describe an unusual case of female patient who developed autoimmune CDI following ureaplasma urealyticum infection and to review the literature on this uncommon feature. Moreover, we also discussed the potential mechanisms by which ureaplasma urealyticum might favor the development of autoimmune CDI.
AB - Diabetes insipidus is a disease in which large volumes of dilute urine (polyuria) are excreted due to vasopressin (AVP) deficiency [central diabetes insipidus (CDI)] or to AVP resistance (nephrogenic diabetes insipidus). In the majority of patients, the occurrence of CDI is related to the destruction or degeneration of neurons of the hypothalamic supraoptic and paraventricular nuclei. The most common and well recognized causes include local inflammatory or autoimmune diseases, vascular disorders, Langerhans cell histiocytosis (LCH), sarcoidosis, tumors such as germinoma/craniopharyngioma or metastases, traumatic brain injuries, intracranial surgery, and midline cerebral and cranial malformations. Here we have the opportunity to describe an unusual case of female patient who developed autoimmune CDI following ureaplasma urealyticum infection and to review the literature on this uncommon feature. Moreover, we also discussed the potential mechanisms by which ureaplasma urealyticum might favor the development of autoimmune CDI.
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UR - http://www.scopus.com/inward/citedby.url?scp=84979626051&partnerID=8YFLogxK
U2 - 10.1590/2359-3997000000072
DO - 10.1590/2359-3997000000072
M3 - Article
C2 - 26331225
AN - SCOPUS:84979626051
VL - 59
SP - 554
EP - 558
JO - Archives of endocrinology and metabolism
JF - Archives of endocrinology and metabolism
SN - 2359-3997
IS - 6
ER -