Autoimmune central diabetes insipidus in a patient with ureaplasma urealyticum infection and review on new triggers of immune response

Giuseppe Murdaca, Rodolfo Russo, Francesca Spanò, Diego Ferone, Manuela Albertelli, Angelo Schenone, Miriam Contatore, Andrea Guastalla, Annamaria De Bellis, Giacomo Garibotto, Francesco Puppo

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Abstract

Diabetes insipidus is a disease in which large volumes of dilute urine (polyuria) are excreted due to vasopressin (AVP) deficiency [central diabetes insipidus (CDI)] or to AVP resistance (nephrogenic diabetes insipidus). In the majority of patients, the occurrence of CDI is related to the destruction or degeneration of neurons of the hypothalamic supraoptic and paraventricular nuclei. The most common and well recognized causes include local inflammatory or autoimmune diseases, vascular disorders, Langerhans cell histiocytosis (LCH), sarcoidosis, tumors such as germinoma/craniopharyngioma or metastases, traumatic brain injuries, intracranial surgery, and midline cerebral and cranial malformations. Here we have the opportunity to describe an unusual case of female patient who developed autoimmune CDI following ureaplasma urealyticum infection and to review the literature on this uncommon feature. Moreover, we also discussed the potential mechanisms by which ureaplasma urealyticum might favor the development of autoimmune CDI.

Original languageEnglish
Pages (from-to)554-558
Number of pages5
JournalArchives of endocrinology and metabolism
Volume59
Issue number6
DOIs
Publication statusPublished - Dec 1 2015

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Ureaplasma Infections
Neurogenic Diabetes Insipidus
Ureaplasma urealyticum
Type 1 Diabetes Mellitus
Nephrogenic Diabetes Insipidus
Germinoma
Craniopharyngioma
Polyuria
Supraoptic Nucleus
Nerve Degeneration
Langerhans Cell Histiocytosis
Diabetes Insipidus
Sarcoidosis
Autoimmune Diseases
Blood Vessels
Urine
Neoplasm Metastasis
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

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Autoimmune central diabetes insipidus in a patient with ureaplasma urealyticum infection and review on new triggers of immune response. / Murdaca, Giuseppe; Russo, Rodolfo; Spanò, Francesca; Ferone, Diego; Albertelli, Manuela; Schenone, Angelo; Contatore, Miriam; Guastalla, Andrea; De Bellis, Annamaria; Garibotto, Giacomo; Puppo, Francesco.

In: Archives of endocrinology and metabolism, Vol. 59, No. 6, 01.12.2015, p. 554-558.

Research output: Contribution to journalArticle

Murdaca, G, Russo, R, Spanò, F, Ferone, D, Albertelli, M, Schenone, A, Contatore, M, Guastalla, A, De Bellis, A, Garibotto, G & Puppo, F 2015, 'Autoimmune central diabetes insipidus in a patient with ureaplasma urealyticum infection and review on new triggers of immune response', Archives of endocrinology and metabolism, vol. 59, no. 6, pp. 554-558. https://doi.org/10.1590/2359-3997000000072
Murdaca, Giuseppe ; Russo, Rodolfo ; Spanò, Francesca ; Ferone, Diego ; Albertelli, Manuela ; Schenone, Angelo ; Contatore, Miriam ; Guastalla, Andrea ; De Bellis, Annamaria ; Garibotto, Giacomo ; Puppo, Francesco. / Autoimmune central diabetes insipidus in a patient with ureaplasma urealyticum infection and review on new triggers of immune response. In: Archives of endocrinology and metabolism. 2015 ; Vol. 59, No. 6. pp. 554-558.
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