Autoimmune cytopenias in chronic lymphocytic leukemia

Carlo Visco, Wilma Barcellini, Francesco Maura, Antonino Neri, Agostino Cortelezzi, Francesco Rodeghiero

Research output: Contribution to journalReview article

Abstract

Chronic lymphocytic leukemia (CLL) is frequently complicated by secondary autoimmune cytopenias (AIC) represented by autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), pure red cell aplasia, and autoimmune granulocytopenia. The distinction of immune cytopenias from cytopenias due to bone marrow infiltration, usually associated with a worse outcome and often requiring a different treatment, is mandatory. AIHA and ITP are more frequently found in patients with unfavorable biological risk factors for CLL. AIC secondary to CLL respond less favorably to standard treatments than their primary forms, and treating the underlying CLL with chemotherapy or monoclonal antibodies may ultimately be necessary. Am. J. Hematol. 89:1055–1062, 2014.

Original languageEnglish
Pages (from-to)1055-1062
Number of pages8
JournalAmerican Journal of Hematology
Volume89
Issue number11
DOIs
Publication statusPublished - Nov 1 2014

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ASJC Scopus subject areas

  • Hematology

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