Autoimmune disorders in patients affected by celiac sprue and inflammatory bowel disease

Maria Teresa Bardella, Luca Elli, Sara De Matteis, Irene Floriani, Valter Torri, Luca Piodi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background. Although clinically different, celiac sprue and inflammatory bowel disease are characterized by chronic intestinal inflammation and associated extraintestinal manifestations. Aims. To assess and compare the presence of autoimmune disorders in patients affected by celiac sprue and inflammatory bowel disease referred to a single tertiary centre. Methods. From October 2005 to January 2006, a total of 297 consecutive outpatients were enrolled in this cross-sectional study. Diagnoses of celiac sprue and inflammatory bowel disease were based on standard criteria. Data were recorded using an operator-assisted questionnaire: 18 autoimmune diseases, when adequately confirmed, were considered. Results. Clinical characteristics of our patients are in conformity with those of the literature. The prevalence of associated autoimmune diseases was 25.6%, 21.1%, and 10% in patients affected by celiac sprue, Crohn's disease, and ulcerative colitis. Between the prevalence in celiac sprue and Crohn's disease there was no difference, whereas a significant difference was present between these two diseases and ulcerative colitis. The most frequent disorder in all three groups was Hashimoto's thyroiditis. Conclusions. Celiac sprue and Crohn's disease show similar prevalence of associated autoimmune disease, higher than the prevalence in ulcerative colitis. The two diseases share the same pathogenic immunologic response and altered intestinal permeability.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalAnnals of Medicine
Volume41
Issue number2
DOIs
Publication statusPublished - 2009

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Celiac Disease
Inflammatory Bowel Diseases
Ulcerative Colitis
Crohn Disease
Autoimmune Diseases
Hashimoto Disease
Permeability
Outpatients
Cross-Sectional Studies
Inflammation

Keywords

  • Autoimmune disease
  • Celiac sprue
  • Hashimoto's thyroiditis
  • Inflammatory bowel disease

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Autoimmune disorders in patients affected by celiac sprue and inflammatory bowel disease. / Bardella, Maria Teresa; Elli, Luca; Matteis, Sara De; Floriani, Irene; Torri, Valter; Piodi, Luca.

In: Annals of Medicine, Vol. 41, No. 2, 2009, p. 139-143.

Research output: Contribution to journalArticle

Bardella, Maria Teresa ; Elli, Luca ; Matteis, Sara De ; Floriani, Irene ; Torri, Valter ; Piodi, Luca. / Autoimmune disorders in patients affected by celiac sprue and inflammatory bowel disease. In: Annals of Medicine. 2009 ; Vol. 41, No. 2. pp. 139-143.
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