Autoimmune hemolytic anemias

Sigbjørn Berentsen, Wilma Barcellini

Research output: Contribution to journalReview articlepeer-review


Autoimmune hemolytic anemia (AIHA) is defined as increased destruction of red cells through autoimmune mechanisms, usually mediated by autoantibodies against erythrocyte surface antigens. During the past decade, important new findings have emerged regarding the cause, pathogenesis, diagnosis, and treatment of this group of disorders. Historically, clinical practice was based on theoretical considerations, case reports, and expert opinion, but more recently, several prospective and other systematic clinical studies have been conducted. The first international consensus on diagnosis and therapy was published in 2020, and British guidelines have also been reported. Challenges remain, however, including a wider application of current knowledge, an improved understanding of pathogenesis, development of new therapies, and management of refractory cases. AIHA is a common term for several diseases that differ from one another with respect to cause, pathogenesis, and clinical presentation, and the individual disorders should be addressed according to these differences (Table 1).

Original languageEnglish
Pages (from-to)1407-1419
Number of pages13
JournalNew England Journal of Medicine
Issue number15
Publication statusPublished - Oct 7 2021

ASJC Scopus subject areas

  • Medicine(all)


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