Autoimmune hepatitis type 2 following anti-papillomavirus vaccination in a 11-year-old girl

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Abstract

In the last years numerous reports describing a possible association between administration of vaccines and development of autoimmune phenomena and overt autoimmune disease were published. Possible mechanisms of induction of autoimmune phenomena by vaccines and their excipients are probably similar to those implicated in induction by infectious agents. Here we report the case of an 11-year-old girl who developed autoimmune hepatitis type II after four weeks from vaccination against human papillomavirus. The possible relationships between the use of adjuvated vaccine against papillomavirus and autoimmune hepatitis are discussed. Although we do not provide evidence for a causal link, we suggest that the occurrence of the autoimmune hepatitis may be related to the stimulation of immune system by adjuvated-vaccine, that could have triggered the disease in a genetically predisposed individual. Therefore a monitoring of liver function test following administration of vaccine against papillomavirus may be useful in adolescent girl with signs of hepatopathy, as jaundice, dark urine or hepatomegaly, to early identify and to promptly treat autoimmune liver disorders.

Original languageEnglish
Pages (from-to)4654-4656
Number of pages3
JournalVaccine
Volume29
Issue number29-30
DOIs
Publication statusPublished - Jun 24 2011

Fingerprint

autoimmune hepatitis
Autoimmune Hepatitis
Papillomaviridae
Papillomavirus Vaccines
Vaccination
Vaccines
vaccination
vaccines
Hepatomegaly
Excipients
Liver Function Tests
Jaundice
Autoimmune Diseases
Immune System
jaundice
Urine
autoimmune diseases
liver function
Liver
immune system

Keywords

  • Autoimmune hepatitis
  • Children
  • HPV vaccination

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

Cite this

Autoimmune hepatitis type 2 following anti-papillomavirus vaccination in a 11-year-old girl. / Corte, Claudia Della; Carlucci, Antonio; Francalanci, Paola; Alisi, Anna; Nobili, Valerio.

In: Vaccine, Vol. 29, No. 29-30, 24.06.2011, p. 4654-4656.

Research output: Contribution to journalArticle

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