Autoimmune liver diseases and antiphospholipid antibodies positivity: A meta-analysis of literature studies

Pasquale Ambrosino, Roberta Lupoli, Gaia Spadarella, Paolo Tarantino, Alessandro Di Minno, Luciano Tarantino, Matteo Nicola Dario Di Minno

Research output: Contribution to journalArticle

Abstract

Background & Aims: Several studies reported an association between autoimmune liver diseases (AiLD) and antiphospholipid antibodies (aPL) positivity. We performed a meta-analysis of studies evaluating the association of primary biliary cirrhosis (PBC), autoimmune hepatitis (AIH), and primary sclerosing cholangitis (PSC) with aPL positivity and with aPL-related thrombotic events. Methods: Studies evaluating the association of AiLD with aPL (anticardiolipin [aCL], anti-β2 glycoprotein-I [anti-β2GPI], lupus anticoagulant [LA] antibodies) and with aPL-related thrombotic complications were systematically searched in the PubMed, Web of Science, Scopus and EMBASE databases. Results: A total of 10 studies (750 patients with AiLD and 1,244 healthy controls) were included in the analysis on the prevalence of aPL and showed that AiLD are significantly associated with the presence of aCL and anti-β2GPI. The association with aCL positivity was consistently confirmed in PBC (OR: 13.93, 95%CI: 4.69-41.38), AIH (OR: 23.50, 95%CI: 4.28-129.13), and PSC (OR: 18.21, 95%CI: 7.05-47.08). Similarly, anti-β2GPI were found more frequently in PBC (OR: 25.10, 95%CI: 4.77-132.11), AIH (OR: 48.57, 95%CI: 11.07-213.09), and PSC (OR: 36.30, 95%CI: 6.55-201.31). These findings are confirmed when separately analyzing IgM, IgG, and IgA directed against phospholipids. Two of the 10 included articles and 1 further study (67 cases and 75 controls) showed a trend, not achieving statistical significance, towards a higher prevalence of thrombotic complications in AIH patients with aPL as compared to those with only AIH (OR: 1.67, 95%CI: 0.46-6.05). Conclusion: PBC, AIH, and PSC are significantly associated with aPL positivity. The association with aPL-related thrombotic complications should be further studied.

Original languageEnglish
Pages (from-to)25-34
Number of pages10
JournalJournal of Gastrointestinal and Liver Diseases
Volume24
Issue number1
Publication statusPublished - 2015

Fingerprint

Antiphospholipid Antibodies
Autoimmune Diseases
Meta-Analysis
Liver Diseases
Autoimmune Hepatitis
Sclerosing Cholangitis
Biliary Liver Cirrhosis
Glycoproteins
Lupus Coagulation Inhibitor
PubMed
Immunoglobulin A
Immunoglobulin M
Phospholipids
Immunoglobulin G
Databases
Antibodies

Keywords

  • Antiphospholipid antibodies
  • Antiphospholipid syndrome
  • Autoimmune hepatitis
  • Primary biliary cirrhosis
  • Primary sclerosing cholangitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Ambrosino, P., Lupoli, R., Spadarella, G., Tarantino, P., Di Minno, A., Tarantino, L., & Di Minno, M. N. D. (2015). Autoimmune liver diseases and antiphospholipid antibodies positivity: A meta-analysis of literature studies. Journal of Gastrointestinal and Liver Diseases, 24(1), 25-34.

Autoimmune liver diseases and antiphospholipid antibodies positivity : A meta-analysis of literature studies. / Ambrosino, Pasquale; Lupoli, Roberta; Spadarella, Gaia; Tarantino, Paolo; Di Minno, Alessandro; Tarantino, Luciano; Di Minno, Matteo Nicola Dario.

In: Journal of Gastrointestinal and Liver Diseases, Vol. 24, No. 1, 2015, p. 25-34.

Research output: Contribution to journalArticle

Ambrosino, P, Lupoli, R, Spadarella, G, Tarantino, P, Di Minno, A, Tarantino, L & Di Minno, MND 2015, 'Autoimmune liver diseases and antiphospholipid antibodies positivity: A meta-analysis of literature studies', Journal of Gastrointestinal and Liver Diseases, vol. 24, no. 1, pp. 25-34.
Ambrosino P, Lupoli R, Spadarella G, Tarantino P, Di Minno A, Tarantino L et al. Autoimmune liver diseases and antiphospholipid antibodies positivity: A meta-analysis of literature studies. Journal of Gastrointestinal and Liver Diseases. 2015;24(1):25-34.
Ambrosino, Pasquale ; Lupoli, Roberta ; Spadarella, Gaia ; Tarantino, Paolo ; Di Minno, Alessandro ; Tarantino, Luciano ; Di Minno, Matteo Nicola Dario. / Autoimmune liver diseases and antiphospholipid antibodies positivity : A meta-analysis of literature studies. In: Journal of Gastrointestinal and Liver Diseases. 2015 ; Vol. 24, No. 1. pp. 25-34.
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abstract = "Background & Aims: Several studies reported an association between autoimmune liver diseases (AiLD) and antiphospholipid antibodies (aPL) positivity. We performed a meta-analysis of studies evaluating the association of primary biliary cirrhosis (PBC), autoimmune hepatitis (AIH), and primary sclerosing cholangitis (PSC) with aPL positivity and with aPL-related thrombotic events. Methods: Studies evaluating the association of AiLD with aPL (anticardiolipin [aCL], anti-β2 glycoprotein-I [anti-β2GPI], lupus anticoagulant [LA] antibodies) and with aPL-related thrombotic complications were systematically searched in the PubMed, Web of Science, Scopus and EMBASE databases. Results: A total of 10 studies (750 patients with AiLD and 1,244 healthy controls) were included in the analysis on the prevalence of aPL and showed that AiLD are significantly associated with the presence of aCL and anti-β2GPI. The association with aCL positivity was consistently confirmed in PBC (OR: 13.93, 95{\%}CI: 4.69-41.38), AIH (OR: 23.50, 95{\%}CI: 4.28-129.13), and PSC (OR: 18.21, 95{\%}CI: 7.05-47.08). Similarly, anti-β2GPI were found more frequently in PBC (OR: 25.10, 95{\%}CI: 4.77-132.11), AIH (OR: 48.57, 95{\%}CI: 11.07-213.09), and PSC (OR: 36.30, 95{\%}CI: 6.55-201.31). These findings are confirmed when separately analyzing IgM, IgG, and IgA directed against phospholipids. Two of the 10 included articles and 1 further study (67 cases and 75 controls) showed a trend, not achieving statistical significance, towards a higher prevalence of thrombotic complications in AIH patients with aPL as compared to those with only AIH (OR: 1.67, 95{\%}CI: 0.46-6.05). Conclusion: PBC, AIH, and PSC are significantly associated with aPL positivity. The association with aPL-related thrombotic complications should be further studied.",
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AU - Di Minno, Alessandro

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AU - Di Minno, Matteo Nicola Dario

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N2 - Background & Aims: Several studies reported an association between autoimmune liver diseases (AiLD) and antiphospholipid antibodies (aPL) positivity. We performed a meta-analysis of studies evaluating the association of primary biliary cirrhosis (PBC), autoimmune hepatitis (AIH), and primary sclerosing cholangitis (PSC) with aPL positivity and with aPL-related thrombotic events. Methods: Studies evaluating the association of AiLD with aPL (anticardiolipin [aCL], anti-β2 glycoprotein-I [anti-β2GPI], lupus anticoagulant [LA] antibodies) and with aPL-related thrombotic complications were systematically searched in the PubMed, Web of Science, Scopus and EMBASE databases. Results: A total of 10 studies (750 patients with AiLD and 1,244 healthy controls) were included in the analysis on the prevalence of aPL and showed that AiLD are significantly associated with the presence of aCL and anti-β2GPI. The association with aCL positivity was consistently confirmed in PBC (OR: 13.93, 95%CI: 4.69-41.38), AIH (OR: 23.50, 95%CI: 4.28-129.13), and PSC (OR: 18.21, 95%CI: 7.05-47.08). Similarly, anti-β2GPI were found more frequently in PBC (OR: 25.10, 95%CI: 4.77-132.11), AIH (OR: 48.57, 95%CI: 11.07-213.09), and PSC (OR: 36.30, 95%CI: 6.55-201.31). These findings are confirmed when separately analyzing IgM, IgG, and IgA directed against phospholipids. Two of the 10 included articles and 1 further study (67 cases and 75 controls) showed a trend, not achieving statistical significance, towards a higher prevalence of thrombotic complications in AIH patients with aPL as compared to those with only AIH (OR: 1.67, 95%CI: 0.46-6.05). Conclusion: PBC, AIH, and PSC are significantly associated with aPL positivity. The association with aPL-related thrombotic complications should be further studied.

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