Autoimmune myastenia gravis with thymoma following the spontaneous remission of stiff-man syndrome

G. Piccolo, G. Martino, A. Moglia, A. Arrigo, V. Cosi

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A patient who developed generalized autoimmune myasthenia gravis six years after the spontaneous remission of a stiff-man syndrome is described. He also suffered from chronic active hepatitis and had radiological evidence of a thymoma. He did not have diabetes mellitus. Besides anti-nicotinic acetylcholine receptor antibodies, anti-nuclear, anti-DNA, anti-mitochondrial and anti-skeletal muscle antibodies were found in his serum, while islet-cell antibodies were absent. Immunocytochemistry studies failed to demonstrate autoantibodies to GABA-ergic nerve terminals, although an aspecific neuronal immunostaining was observed. The clinical and immunological features of this case support the hypothesis of a dysimmune pathogenesis of SMS, also in cases not associated with autoimmunity to GABA-ergic nerve terminals. Furthermore, a relationship between thymoma and the neurological syndromes discussed could be considered.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalItalian Journal of Neurological Sciences
Issue number2
Publication statusPublished - Apr 1990


  • autoimmune myasthenia gravis
  • paraneoplastic neurological syndromes
  • Stiff-man syndrome

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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