Autoimmune neuromuscular disease induced by a preparation of choline acetyltransferase

Li Pen Chao, K. S Karen Kan, Corrado Angelini, John Keesey

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

An apparent fatal autoimmune disease was induced in guinea pigs by injection of a preparation of choline acetyltransferase in complete Freund's adjuvant. The animals probably died from respiratory failure based on the evidence from clinical, histological, and histochemical examination. At autopsy the pathogenic lesions were located at the neuromuscular junctions and near the nerves where choline actyltransferase was found. It is further proposed that this is a presynaptic autoimmune neuromuscular disease based on the finding of numerous target, as well as targetoid, fibers in muscle after histochemical staining. There was also denervation shown by electromyographic measurements in the form of positive sharp waves as well as fibrillation discharges.

Original languageEnglish
Pages (from-to)23-35
Number of pages13
JournalExperimental Neurology
Volume75
Issue number1
DOIs
Publication statusPublished - 1982

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Neuromuscular Diseases
Choline O-Acetyltransferase
Autoimmune Diseases
Freund's Adjuvant
Neuromuscular Junction
Denervation
Choline
Respiratory Insufficiency
Autopsy
Guinea Pigs
Staining and Labeling
Muscles
Injections

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

Cite this

Autoimmune neuromuscular disease induced by a preparation of choline acetyltransferase. / Chao, Li Pen; Kan, K. S Karen; Angelini, Corrado; Keesey, John.

In: Experimental Neurology, Vol. 75, No. 1, 1982, p. 23-35.

Research output: Contribution to journalArticle

Chao, Li Pen ; Kan, K. S Karen ; Angelini, Corrado ; Keesey, John. / Autoimmune neuromuscular disease induced by a preparation of choline acetyltransferase. In: Experimental Neurology. 1982 ; Vol. 75, No. 1. pp. 23-35.
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