Neuropatie disimmuni in corso di gammopatie monoclonali.

Translated title of the contribution: Autoimmune neuropathy in monoclonal gammopathy

L. Guardigni, F. Rasi, R. Nemni, I. Lorenzetti, F. Valzania, E. Pretolani

Research output: Contribution to journalArticlepeer-review


The relationship between polyneuropathies and monoclonal gammopathies is well known even though the pathogenetic hypotheses are controversial. The role of autoantibodies against neural antigens has been recently underlined. 45 patients (29 M and 16 F), affected by multiple myeloma (MM) non-Hodgkin lymphoma (NHL) with paraproteinemia and monoclonal gammopathies of undetermined significance (MGUS)4, underwent an EMG study including SCV, MCV and late responses of several nerves, and a search for serum antibodies against neural antigens by immunoblotting assay. 19 out of 45 pts. tested positive to EMG and 15 out of 45 (10 MM and 5 NHL) showed a serological positivity. Among them 11 were positive to EMG too. The results confirm the hypothesis of a possible pathogenetic role of high-titer autoantibodies against neural antigens in cases of polyneuropathy.

Translated title of the contributionAutoimmune neuropathy in monoclonal gammopathy
Original languageItalian
Pages (from-to)669-671
Number of pages3
JournalRecenti Progressi in Medicina
Issue number12
Publication statusPublished - Dec 1991

ASJC Scopus subject areas

  • Medicine(all)


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