Autoimmune pituitary involvement in Prader-Willi syndrome

Italian Autoimmune Hypophysitis Network Study and of the Genetic Obesity Study Group of the Italian Society of Pediatric Endocrinologyand Diabetology (ISPED), Graziano Grugni, Antonino Crinò, Annamaria De Bellis, Alessio Convertino, Sarah Bocchini, Sabrina Maestrini, Paolo Cirillo, Silvana De Lucia, Maurizio Delvecchio

Research output: Contribution to journal › Article

Abstract

The role of antipituitary antibodies in the pathophysiology of pituitary hormone deficiency has been increasingly elucidated over the last decade. Prader-Willi syndrome is a genetic disorder which includes hypothalamic/pituitary dysfunction as one of its main features. We looked for autoimmune pituitary involvement in 55 adults with Prader-Willi syndrome, discovering that about 30% of them have a positive titer of antipituitary antibodies. Although the presence of these autoantibodies could only be an "epiphenomenon", our results suggest that autoimmune mechanisms might contribute, at least in part, to the pituitary impairment of Prader-Willi syndrome, and in addition to genetically determined dysfunction of the central nervous system. This paper provides a new perspective on pituitary impairment in these patients, suggesting that the search for hypophisitis could be a reasonable and interesting field for further research.
Original languageItalian
JournalEndocrine
DOIs
Publication statusPublished - Jul 2 2018

Cite this

(ISPED), I. A. H. N. S. A. O. T. G. O. S. G. O. T. I. S. O. P. E. D., Grugni, G., Crinò, A., De Bellis, A., Convertino, A., Bocchini, S., ... Delvecchio, M. (2018). Autoimmune pituitary involvement in Prader-Willi syndrome. Endocrine. https://doi.org/10.1007/s12020-018-1666-5

Autoimmune pituitary involvement in Prader-Willi syndrome. / (ISPED), Italian Autoimmune Hypophysitis Network Study and of the Genetic Obesity Study Group of the Italian Society of Pediatric Endocrinologyand Diabetology; Grugni, Graziano; Crinò, Antonino; De Bellis, Annamaria; Convertino, Alessio; Bocchini, Sarah; Maestrini, Sabrina; Cirillo, Paolo; De Lucia, Silvana; Delvecchio, Maurizio.

In: Endocrine, 02.07.2018.

Research output: Contribution to journal › Article

(ISPED), IAHNSAOTGOSGOTISOPED, Grugni, G, Crinò, A, De Bellis, A, Convertino, A, Bocchini, S, Maestrini, S, Cirillo, P, De Lucia, S & Delvecchio, M 2018, 'Autoimmune pituitary involvement in Prader-Willi syndrome', Endocrine. https://doi.org/10.1007/s12020-018-1666-5
(ISPED) IAHNSAOTGOSGOTISOPED, Grugni G, Crinò A, De Bellis A, Convertino A, Bocchini S et al. Autoimmune pituitary involvement in Prader-Willi syndrome. Endocrine. 2018 Jul 2. https://doi.org/10.1007/s12020-018-1666-5
(ISPED), Italian Autoimmune Hypophysitis Network Study and of the Genetic Obesity Study Group of the Italian Society of Pediatric Endocrinologyand Diabetology ; Grugni, Graziano ; Crinò, Antonino ; De Bellis, Annamaria ; Convertino, Alessio ; Bocchini, Sarah ; Maestrini, Sabrina ; Cirillo, Paolo ; De Lucia, Silvana ; Delvecchio, Maurizio. / Autoimmune pituitary involvement in Prader-Willi syndrome. In: Endocrine. 2018.
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AU - Grugni, Graziano

AU - Crinò, Antonino

AU - De Bellis, Annamaria

AU - Convertino, Alessio

AU - Bocchini, Sarah

AU - Maestrini, Sabrina

AU - Cirillo, Paolo

AU - De Lucia, Silvana

AU - Delvecchio, Maurizio

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N2 - The role of antipituitary antibodies in the pathophysiology of pituitary hormone deficiency has been increasingly elucidated over the last decade. Prader-Willi syndrome is a genetic disorder which includes hypothalamic/pituitary dysfunction as one of its main features. We looked for autoimmune pituitary involvement in 55 adults with Prader-Willi syndrome, discovering that about 30% of them have a positive titer of antipituitary antibodies. Although the presence of these autoantibodies could only be an "epiphenomenon", our results suggest that autoimmune mechanisms might contribute, at least in part, to the pituitary impairment of Prader-Willi syndrome, and in addition to genetically determined dysfunction of the central nervous system. This paper provides a new perspective on pituitary impairment in these patients, suggesting that the search for hypophisitis could be a reasonable and interesting field for further research.

AB - The role of antipituitary antibodies in the pathophysiology of pituitary hormone deficiency has been increasingly elucidated over the last decade. Prader-Willi syndrome is a genetic disorder which includes hypothalamic/pituitary dysfunction as one of its main features. We looked for autoimmune pituitary involvement in 55 adults with Prader-Willi syndrome, discovering that about 30% of them have a positive titer of antipituitary antibodies. Although the presence of these autoantibodies could only be an "epiphenomenon", our results suggest that autoimmune mechanisms might contribute, at least in part, to the pituitary impairment of Prader-Willi syndrome, and in addition to genetically determined dysfunction of the central nervous system. This paper provides a new perspective on pituitary impairment in these patients, suggesting that the search for hypophisitis could be a reasonable and interesting field for further research.

U2 - 10.1007/s12020-018-1666-5

DO - 10.1007/s12020-018-1666-5

M3 - Articolo

JO - Endocrine

JF - Endocrine

SN - 1355-008X

ER -

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