Autoimmune thyroid disease: New models of cell death in autoimmunity

Giorgio Stassi, Ruggero De Maria

Research output: Contribution to journalArticle

Abstract

Autoimmunity to thyroid antigens leads to two distinct pathogenic processes with opposing clinical outcomes: hypothyroidism in Hashimoto's thyroiditis and hyperthyroidism in Graves' disease. The high frequency of these diseases and easy accessibility of the thyroid gland has allowed the identification of key pathogenic mechanisms in organ-specific autoimmune diseases. In early investigations, antibody- and T-cell-mediated death mechanisms were proposed as being responsible for autoimmune thyrocyte depletion. Later, studies on apoptosis have provided new insights into autoimmune target destruction, indicating the involvement of death receptors and cytokine-regulated apoptotic pathways in the pathogenesis of thyroid autoimmunity.

Original languageEnglish
Pages (from-to)195-204
Number of pages10
JournalNature Reviews Immunology
Volume2
Issue number3
Publication statusPublished - Mar 2002

ASJC Scopus subject areas

  • Immunology

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