Abstract
| Original language | Undefined/Unknown |
|---|---|
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| Journal | Clinical Immunology |
| Volume | 203 |
| DOIs | |
| Publication status | Published - Jun 1 2019 |
| Externally published | Yes |
Cite this
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases. / Watad, Abdulla; Bragazzi, Nicola Luigi; McGonagl, Dennis; Adawi, Mohammed; Bridgewood, Charlie; Damiani, Giovanni; Alijotas-Reig, Jaume; Esteve-Valverde, Enrique; Quaresma, Mariana; Amital, Howard; Shoenfeld, Yehuda.
In: Clinical Immunology, Vol. 203, 01.06.2019, p. 1-8.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases
AU - Watad, Abdulla
AU - Bragazzi, Nicola Luigi
AU - McGonagl, Dennis
AU - Adawi, Mohammed
AU - Bridgewood, Charlie
AU - Damiani, Giovanni
AU - Alijotas-Reig, Jaume
AU - Esteve-Valverde, Enrique
AU - Quaresma, Mariana
AU - Amital, Howard
AU - Shoenfeld, Yehuda
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Background We investigated the pattern of reported immune diseases in the international ASIA syndrome registry. Methods: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed. Results: The patient mean age was 43 +/- 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8 respectively, p <0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08-9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81-31.67], p <0.0001). Conclusions: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.
AB - Background We investigated the pattern of reported immune diseases in the international ASIA syndrome registry. Methods: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed. Results: The patient mean age was 43 +/- 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8 respectively, p <0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08-9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81-31.67], p <0.0001). Conclusions: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.
U2 - 10.1016/j.clim.2019.03.007
DO - 10.1016/j.clim.2019.03.007
M3 - Articolo
VL - 203
SP - 1
EP - 8
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
ER -