Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases

Abdulla Watad, Nicola Luigi Bragazzi, Dennis McGonagl, Mohammed Adawi, Charlie Bridgewood, Giovanni Damiani, Jaume Alijotas-Reig, Enrique Esteve-Valverde, Mariana Quaresma, Howard Amital, Yehuda Shoenfeld

Research output: Contribution to journalArticle

Abstract

Background We investigated the pattern of reported immune diseases in the international ASIA syndrome registry. Methods: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed. Results: The patient mean age was 43 +/- 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8 respectively, p <0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08-9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81-31.67], p <0.0001). Conclusions: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.
Original languageUndefined/Unknown
Pages (from-to)1-8
Number of pages8
JournalClinical Immunology
Volume203
DOIs
Publication statusPublished - Jun 1 2019
Externally publishedYes

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Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases. / Watad, Abdulla; Bragazzi, Nicola Luigi; McGonagl, Dennis; Adawi, Mohammed; Bridgewood, Charlie; Damiani, Giovanni; Alijotas-Reig, Jaume; Esteve-Valverde, Enrique; Quaresma, Mariana; Amital, Howard; Shoenfeld, Yehuda.

In: Clinical Immunology, Vol. 203, 01.06.2019, p. 1-8.

Research output: Contribution to journalArticle

Watad, A, Bragazzi, NL, McGonagl, D, Adawi, M, Bridgewood, C, Damiani, G, Alijotas-Reig, J, Esteve-Valverde, E, Quaresma, M, Amital, H & Shoenfeld, Y 2019, 'Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases', Clinical Immunology, vol. 203, pp. 1-8. https://doi.org/10.1016/j.clim.2019.03.007
Watad, Abdulla ; Bragazzi, Nicola Luigi ; McGonagl, Dennis ; Adawi, Mohammed ; Bridgewood, Charlie ; Damiani, Giovanni ; Alijotas-Reig, Jaume ; Esteve-Valverde, Enrique ; Quaresma, Mariana ; Amital, Howard ; Shoenfeld, Yehuda. / Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases. In: Clinical Immunology. 2019 ; Vol. 203. pp. 1-8.
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abstract = "Background We investigated the pattern of reported immune diseases in the international ASIA syndrome registry. Methods: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed. Results: The patient mean age was 43 +/- 17 years and 89{\%} were female. Within the reported immune diseases, 69{\%} were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7{\%} vs 5.8 respectively, p <0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95{\%}CI 1.08-9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95{\%}CI 3.81-31.67], p <0.0001). Conclusions: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.",
author = "Abdulla Watad and Bragazzi, {Nicola Luigi} and Dennis McGonagl and Mohammed Adawi and Charlie Bridgewood and Giovanni Damiani and Jaume Alijotas-Reig and Enrique Esteve-Valverde and Mariana Quaresma and Howard Amital and Yehuda Shoenfeld",
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T1 - Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases

AU - Watad, Abdulla

AU - Bragazzi, Nicola Luigi

AU - McGonagl, Dennis

AU - Adawi, Mohammed

AU - Bridgewood, Charlie

AU - Damiani, Giovanni

AU - Alijotas-Reig, Jaume

AU - Esteve-Valverde, Enrique

AU - Quaresma, Mariana

AU - Amital, Howard

AU - Shoenfeld, Yehuda

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Background We investigated the pattern of reported immune diseases in the international ASIA syndrome registry. Methods: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed. Results: The patient mean age was 43 +/- 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8 respectively, p <0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08-9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81-31.67], p <0.0001). Conclusions: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.

AB - Background We investigated the pattern of reported immune diseases in the international ASIA syndrome registry. Methods: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed. Results: The patient mean age was 43 +/- 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8 respectively, p <0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08-9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81-31.67], p <0.0001). Conclusions: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.

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DO - 10.1016/j.clim.2019.03.007

M3 - Articolo

VL - 203

SP - 1

EP - 8

JO - Clinical Immunology

JF - Clinical Immunology

SN - 1521-6616

ER -