Autoimmunity and diabetic neuropathy

Nicola Canal, Raffaello Nemni

Research output: Contribution to journalArticlepeer-review


Autoimmunity has been implicated in the pathogenesis of diabetic neuropathy. A number of putative target antigens have been investigated in the attempt to find a relationship between the presence of autoantibodies and the presence of neuropathy. Attention has been given to antibodies against nerve growth factor, adrenal medulla, sympathetic and parasympathetic structures, glutamic acid decarboxylase and phospholipids. Data in the literature do not support a clear-cut difference in frequency of positivity or titres between patients with or without diabetic neuropathy. Moreover, it is not clear whether autoantibodies to the above-mentioned antigens, whenever present, play a role in causing nerve damage or if they simply reflect the presence of nerve damage. Longitudinal studies are needed to clarify some conflicting data in the literature.

Original languageEnglish
Pages (from-to)371-373
Number of pages3
JournalClinical Neuroscience
Issue number6
Publication statusPublished - 1997


  • Autoantibody
  • Autoimmunity
  • Diabetes
  • Neuropathy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology


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