Autoimmunity, HLA, gm AND km polymorphisms in Turner's syndrome

D. Larizza, M. Martinetti Bianchi, R. Lorini, M. Maghnie, J. M. Dugoujon, M. Cuccia Belvedere, F. Severi

Research output: Contribution to journalArticlepeer-review

Abstract

Considering the high frequency of autoimmune disorders in Turner's syndrome and the close relationship between autoimmunity, HLA and immunoglobulin constant region gene polymorphisms, we studied 46 patients with Turner's syndrome, by determination of autoantibodies, HLA histoglobulins and Gm and Km allotypes. OSA and in particular PCA resulted significantly more frequent in patients than in the controls. A higher frequency of HLA-A31, B38 antigens and of blanks at HLA-A locus was found in Turner's subjects than in the controls. A31 was significantly more frequent in autoantibody positive patients while B38 was more frequent in autoantibody negative Turner's subjects than in the controls. DR4 antigen was present only in autoantibody negative patients. Gm 3; 23; 5* phenotype was significantly less frequent, while Gm 3; 5* phenotype was more frequent in patients than in controls. Our data confirm the higher incidence of autoimmunity disorders in Turner's syndrome than in normal subjects. Particular HLA and immunoglobulin types seem to mark this condition. The increase in the blank frequency at A locus could be explained by the presence of a rare antigen at HLA-A locus or a particularly elevated homozygous condition in these subjects.

Original languageEnglish
Pages (from-to)69-78
Number of pages10
JournalAutoimmunity
Volume4
Issue number1-2
DOIs
Publication statusPublished - 1989

Keywords

  • Autoimmunity
  • Gm and Km allotypes
  • HLA polymorphisms
  • Turner's syndrome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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