Autoimmunity in partial and generalized epilepsy

S. Iannaccone, L. Ferini-Strambi, S. Smirne, B. Tedesi, B. Sferrazza, I. Lorenzetti, R. Nemni

Research output: Contribution to journalArticlepeer-review

Abstract

The presence of autoantibodies has been proposed as a potential cause of seizures in human. The aim of our study is to test sera from pts (n 129: Partial Epilepsy (PE ) n 75, Generalized Epilepsy (GE) n 54) for anticerebe1lum and anti-GMl antibodies by immunocytochemistry and Western Blot. The presence of anti-cerebellum1 were positive in- 21 of 75 PE pts and 2 of 54 GE pts. Anti-GMl antibodies titers was borderline (1:600) in 2 PE pts and not different from controls in all others pts. Our findings do not support a pathogenetic role of anti-GMl antibodies. The presence of anti-cerebellum antib o-d i e s in 28% of PE pts suggests that a subgroup of PE pts may presence an autoimmune dysregulation.

Original languageEnglish
Pages (from-to)126
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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