The presence of autoantibodies has been proposed as a potential cause of seizures in human. The aim of our study is to test sera from pts (n 129: Partial Epilepsy (PE ) n 75, Generalized Epilepsy (GE) n 54) for anticerebe1lum and anti-GMl antibodies by immunocytochemistry and Western Blot. The presence of anti-cerebellum1 were positive in- 21 of 75 PE pts and 2 of 54 GE pts. Anti-GMl antibodies titers was borderline (1:600) in 2 PE pts and not different from controls in all others pts. Our findings do not support a pathogenetic role of anti-GMl antibodies. The presence of anti-cerebellum antib o-d i e s in 28% of PE pts suggests that a subgroup of PE pts may presence an autoimmune dysregulation.
|Number of pages||1|
|Journal||Italian Journal of Neurological Sciences|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Clinical Neurology