Autoimmunity in vitiligo: Relationship with hla, gm and km polymorphisms

R. Lorini, G. Orecchia, M. Martinetti, J. M. Dugoujon, M. Cuccia

Research output: Contribution to journalArticlepeer-review

Abstract

Eighty-six patients affected by vitiligo were investigated for Gm, and Km polymorphisms, HLA markers and the presence of organ and non organ-specific autoantibodies. Vitiligo patients had an increased frequency of autoantibodies (71% in particular anti-parietal cells (26.6% antithyroglobulin (24.4% and antithyroid microsomal antibodies (43% One patient was also affected by Hashimoto's thyroiditis, 4 by Graves' disease and two others by nontoxic, multinodular goiter. No correlation was found between chronologic age and sex and the presence of autoantibodies, while an increased frequency of organ-specific autoantibodies was found with longer duration of vitiligo. HLA-A3 and Gm (3; 23; 5, 10, 11, 13, 14) phenotype frequencies were significantly increased in patients without autoantibodies (P

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalAutoimmunity
Volume11
Issue number4
DOIs
Publication statusPublished - 1992

Keywords

  • Autoantibodies
  • HLA polymorphisms, Gm and Km allotypes
  • Vitiligo

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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