Autoimmunity in vitiligo: Relationship with hla, gm and km polymorphisms

R. Lorini, G. Orecchia, M. Martinetti, J. M. Dugoujon, M. Cuccia

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Eighty-six patients affected by vitiligo were investigated for Gm, and Km polymorphisms, HLA markers and the presence of organ and non organ-specific autoantibodies. Vitiligo patients had an increased frequency of autoantibodies (71% in particular anti-parietal cells (26.6% antithyroglobulin (24.4% and antithyroid microsomal antibodies (43% One patient was also affected by Hashimoto's thyroiditis, 4 by Graves' disease and two others by nontoxic, multinodular goiter. No correlation was found between chronologic age and sex and the presence of autoantibodies, while an increased frequency of organ-specific autoantibodies was found with longer duration of vitiligo. HLA-A3 and Gm (3; 23; 5, 10, 11, 13, 14) phenotype frequencies were significantly increased in patients without autoantibodies (P

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalAutoimmunity
Volume11
Issue number4
DOIs
Publication statusPublished - 1992

Fingerprint

Vitiligo
Autoimmunity
Autoantibodies
HLA-A3 Antigen
Hashimoto Disease
Graves Disease
Goiter
Phenotype
Antibodies

Keywords

  • Autoantibodies
  • HLA polymorphisms, Gm and Km allotypes
  • Vitiligo

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Lorini, R., Orecchia, G., Martinetti, M., Dugoujon, J. M., & Cuccia, M. (1992). Autoimmunity in vitiligo: Relationship with hla, gm and km polymorphisms. Autoimmunity, 11(4), 255-260. https://doi.org/10.3109/08916939209035163

Autoimmunity in vitiligo : Relationship with hla, gm and km polymorphisms. / Lorini, R.; Orecchia, G.; Martinetti, M.; Dugoujon, J. M.; Cuccia, M.

In: Autoimmunity, Vol. 11, No. 4, 1992, p. 255-260.

Research output: Contribution to journalArticle

Lorini, R, Orecchia, G, Martinetti, M, Dugoujon, JM & Cuccia, M 1992, 'Autoimmunity in vitiligo: Relationship with hla, gm and km polymorphisms', Autoimmunity, vol. 11, no. 4, pp. 255-260. https://doi.org/10.3109/08916939209035163
Lorini, R. ; Orecchia, G. ; Martinetti, M. ; Dugoujon, J. M. ; Cuccia, M. / Autoimmunity in vitiligo : Relationship with hla, gm and km polymorphisms. In: Autoimmunity. 1992 ; Vol. 11, No. 4. pp. 255-260.
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