Abstract
Autoinflammatory diseases represent an expanding spectrum of genetic and non-genetic inflammatory diseases characterized by recurrent episodes of fever and systemic inflammation affecting the eyes, joints, skin, and serosal surfaces. Thus, these syndromes are recognized as disorders of innate immunity. Confirming this view, most autoinflammatory diseases are uniquely responsive to IL-1β blockade. Although many autoinflammatory diseases have a genetic cause, increasing evidence indicates that the degree of cell stress concurs to the severity of the disease phenotype. In this mini-review, I will discuss the recent advances on pathogenesis, pathophysiology and therapeutic approaches in autoinflammatory syndromes.
| Original language | English |
|---|---|
| Pages (from-to) | 226-230 |
| Number of pages | 5 |
| Journal | Immunology Letters |
| Volume | 161 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Autoimmune
- Autoinflammatory
- Biologics
- IL-1
- NOD-like receptors
- Stress
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Medicine(all)
Cite this
Autoinflammatory diseases. / Rubartelli, Anna.
In: Immunology Letters, Vol. 161, No. 2, 2014, p. 226-230.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Autoinflammatory diseases
AU - Rubartelli, Anna
PY - 2014
Y1 - 2014
N2 - Autoinflammatory diseases represent an expanding spectrum of genetic and non-genetic inflammatory diseases characterized by recurrent episodes of fever and systemic inflammation affecting the eyes, joints, skin, and serosal surfaces. Thus, these syndromes are recognized as disorders of innate immunity. Confirming this view, most autoinflammatory diseases are uniquely responsive to IL-1β blockade. Although many autoinflammatory diseases have a genetic cause, increasing evidence indicates that the degree of cell stress concurs to the severity of the disease phenotype. In this mini-review, I will discuss the recent advances on pathogenesis, pathophysiology and therapeutic approaches in autoinflammatory syndromes.
AB - Autoinflammatory diseases represent an expanding spectrum of genetic and non-genetic inflammatory diseases characterized by recurrent episodes of fever and systemic inflammation affecting the eyes, joints, skin, and serosal surfaces. Thus, these syndromes are recognized as disorders of innate immunity. Confirming this view, most autoinflammatory diseases are uniquely responsive to IL-1β blockade. Although many autoinflammatory diseases have a genetic cause, increasing evidence indicates that the degree of cell stress concurs to the severity of the disease phenotype. In this mini-review, I will discuss the recent advances on pathogenesis, pathophysiology and therapeutic approaches in autoinflammatory syndromes.
KW - Autoimmune
KW - Autoinflammatory
KW - Biologics
KW - IL-1
KW - NOD-like receptors
KW - Stress
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U2 - 10.1016/j.imlet.2013.12.013
DO - 10.1016/j.imlet.2013.12.013
M3 - Article
C2 - 24452074
AN - SCOPUS:84906793904
VL - 161
SP - 226
EP - 230
JO - Immunology Letters
JF - Immunology Letters
SN - 0165-2478
IS - 2
ER -