Autoinflammatory diseases

Anna Rubartelli

Research output: Contribution to journalArticlepeer-review

Abstract

Autoinflammatory diseases represent an expanding spectrum of genetic and non-genetic inflammatory diseases characterized by recurrent episodes of fever and systemic inflammation affecting the eyes, joints, skin, and serosal surfaces. Thus, these syndromes are recognized as disorders of innate immunity. Confirming this view, most autoinflammatory diseases are uniquely responsive to IL-1β blockade. Although many autoinflammatory diseases have a genetic cause, increasing evidence indicates that the degree of cell stress concurs to the severity of the disease phenotype. In this mini-review, I will discuss the recent advances on pathogenesis, pathophysiology and therapeutic approaches in autoinflammatory syndromes.

Original languageEnglish
Pages (from-to)226-230
Number of pages5
JournalImmunology Letters
Volume161
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • Autoimmune
  • Autoinflammatory
  • Biologics
  • IL-1
  • NOD-like receptors
  • Stress

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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