Autologous bone marrow transplantation for adult advanced stage lymphoblastic lymphoma in first CR. A study of the NHLCSG

G. Santini, A. M. Congiu, P. Coser, T. Chisesi, A. Porcellini, R. Sertoli, A. Contu, O. Vinante, D. Pierluigi, V. Vitale, A. Rubagotti, P. Orcamo, V. Rizzoli

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Abstract

Fourty successive adult patients with lymphoblastic lymphoma entered a study of sequential chemotherapy consisting of an intensive LSA-L2-type protocol to induce first complete remission. Twenty-one patients in first CR (median age 24 years, range 15-43), after receiving a conditioning regimen consisting of cyclophosphamide and total body irradiation, underwent autologous bone marrow transplantation. At this time fourtheen patients are alive and well 5-72 months post-transplant (median follow-up 58 months) with an actuarial disease free survival of 66%. These early results suggest that high-dose chemoradiotherapy followed by autologous bone marrow transplantation may improve long-term disease free survival in advanced stage adult lymphoblastic lymphoma.

Original languageEnglish
Pages (from-to)42-45
Number of pages4
JournalLeukemia
Volume5
Issue numberSUPPL. 1
Publication statusPublished - 1991

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ASJC Scopus subject areas

  • Cancer Research
  • Hematology

Cite this

Santini, G., Congiu, A. M., Coser, P., Chisesi, T., Porcellini, A., Sertoli, R., Contu, A., Vinante, O., Pierluigi, D., Vitale, V., Rubagotti, A., Orcamo, P., & Rizzoli, V. (1991). Autologous bone marrow transplantation for adult advanced stage lymphoblastic lymphoma in first CR. A study of the NHLCSG. Leukemia, 5(SUPPL. 1), 42-45.