Autologous bone marrow transplantation for advanced stage adult lymphobastic lymphoma in first complete remission

G. Santini, P. Coser, T. Chisesi, A. Porcellini, R. Sertoli, A. Contu, O. Vinante, A. M. Congiu, A. M. Carella, T. D'Amico, D. Pierluigi, E. Rossi, D. Scarpati, V. Rizzoli

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Abstract

Thirty-six successive adult patients with lymphoblastic lymphoma entered a study of sequential chemotherapy consisting of an intensive LSA2-L2-type protocol to induce first complete remission. Eighteen patients in first CR (median age 22 years, range 15-51), underwent autologous bone marrow transplantation after receiving a conditioning regimen consisting of cyclophosphamide and total body irradiation. Of these 18 patients, 2 were in stage III and 16 in stage IV; 15 showed mediastinal and 9 bone marrow involvement at diagnosis. The transplant procedure was well tolerated and no treatment-induced deaths occurred. At this time, 14 out of 18 patients are alive and well between 1 and 60 months post transplant (median follow-up time 46 months) with an actuarial disease-free survival of 74%. This phase II study suggests that high-dose chemo-radiotherapy followed by autologous bone marrow transplantation may improve long-term disease-free survival in advanced stage adult lymphoblastic lymphoma.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalAnnals of Oncology
Volume2
Issue numberSUPPL. 2
Publication statusPublished - 1991

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Santini, G., Coser, P., Chisesi, T., Porcellini, A., Sertoli, R., Contu, A., Vinante, O., Congiu, A. M., Carella, A. M., D'Amico, T., Pierluigi, D., Rossi, E., Scarpati, D., & Rizzoli, V. (1991). Autologous bone marrow transplantation for advanced stage adult lymphobastic lymphoma in first complete remission. Annals of Oncology, 2(SUPPL. 2), 181-185.