Autologous bone marrow transplantation for childhood acute lymphoblastic leukaemia in Italy

C. Messina, S. Cesaro, R. Rondelli, F. Rossetti, F. Locatelli, A. Pession, R. Miniero, G. Dini, C. Uderzo, S. Dallorso, G. Meloni, M. Vignetti, M. Andolina, F. Porta, A. Amici, C. Favre, G. Basso, G. Sotti, S. Varotto, R. DestroM. V. Gazzola, M. Pillon, M. G. Petris, M. Rabusin, G. Scarzello, L. Zanesco

Research output: Contribution to journalArticle

Abstract

From January 1984 to December 1994, ABMT was performed on 154 children (101 males, 53 females; median age 10, range 3-21 years) with ALL and registered for BMT by the AIEOP (Italian Association of Paediatric Haemato-Oncology). All patients were in CR: 98 were in 2nd CR and 56 were in > 2nd CR. Fifteen children (9.7%) died of transplant-related mortality. Ninety-five patients (61.6%) relapsed at a median of 5 (range 1-42) months after ABMT. The 8-year EFS according to preBMT status was 34.6% (s.e. 4.9) for 2nd CR patients and 10.6% (s.e. 5.6) for patients in > 2nd CR. By univariate analysis, site of relapse (isolated extramedullary (IE) vs BM: EFS = 68.5% vs 18.2%; P <0.0001) and TBI containing regimen (TBI vs no TBI: EFS = 48.1 vs 15.4%; P = 0.0023) were significant factors for 2nd CR patients. When the 2nd CR subset with BM involvement was analysed, TBI became insignificant (EFS = 25.4 vs 11.8%). No factors influenced EFS in patients in > 2nd CR. By multivariate analysis, site of relapse was the only significant factor in 2nd CR patients (P <0.0001). In conclusion, ABMT is an effective treatment after one early IE relapse. Few patients can be rescued after BM relapse.

Original languageEnglish
Pages (from-to)1015-1021
Number of pages7
JournalBone Marrow Transplantation
Volume21
Issue number10
Publication statusPublished - May 2 1998

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Keywords

  • ABMT
  • BM relapse
  • Childhood ALL
  • Isolated extramedullary relapse

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Messina, C., Cesaro, S., Rondelli, R., Rossetti, F., Locatelli, F., Pession, A., Miniero, R., Dini, G., Uderzo, C., Dallorso, S., Meloni, G., Vignetti, M., Andolina, M., Porta, F., Amici, A., Favre, C., Basso, G., Sotti, G., Varotto, S., ... Zanesco, L. (1998). Autologous bone marrow transplantation for childhood acute lymphoblastic leukaemia in Italy. Bone Marrow Transplantation, 21(10), 1015-1021.