Autologous bone marrow transplantation in acute leukemia

L. Mangoni, G. Degliantoni, A. Porcellini, A. M. Carella, E. P. Alessandrino, M. Aglietta, L. Resegott, G. Torlontano, P. Coleselli, R. Mozzana, E. Madon, V. Rizzoli

Research output: Contribution to journalArticle

Abstract

We evaluated the therapeutic efficacy of autologous bone marrow transplantation (ABMT) in 49 patients with acute leukemia, using ex-vivo-treated marrow with mafosfamide. This report summarizes data collected from 8 italian centers, involving 27 cases with acute lymphoid leukemia (ALL) and 22 cases with acute nonlymphoid leukemia (ANLL). The analysis of the results shows that the disease-free survival of ALL and ANLL are similar (45 and 52%, respectively) and no significant difference can be demonstrated between patients transplanted in CR1 or CR2, although there is a trend in favor of ABMT in CR1.

Original languageEnglish
Pages (from-to)190-193
Number of pages4
JournalActa Haematologica
Volume78
DOIs
Publication statusPublished - 1987

Keywords

  • Acute leukemia
  • Autologous bone marrow transplantation
  • Mafosfamide
  • Purging

ASJC Scopus subject areas

  • Hematology

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    Mangoni, L., Degliantoni, G., Porcellini, A., Carella, A. M., Alessandrino, E. P., Aglietta, M., Resegott, L., Torlontano, G., Coleselli, P., Mozzana, R., Madon, E., & Rizzoli, V. (1987). Autologous bone marrow transplantation in acute leukemia. Acta Haematologica, 78, 190-193. https://doi.org/10.1159/000205929