Autologous bone marrow transplantation in non-Hodgkin's lymphoma patients: Effect of a brief course of G-CSF on harvest and recovery

D. Damiani, S. Grimaz, L. Infanti, A. Sperotto, F. Silvestri, A. Geromin, M. Cerno, C. Savignano, M. Michieli, C. Skert, R. Fanin, M. Baccarani

Research output: Contribution to journalArticle

Abstract

This study compares harvest and hematological recovery data of 100 lymphoma patients who underwent BM harvest either after a short course of G-CSF (16 μg/kg for 3 days) (n = 57) or in steady-state conditions (n = 43). G-CSF allowed the attainment of a significantly higher median number of total nucleated cells x 108/kg (4.4, range 1.4-17, vs 2.1, range 0.6-4.2; P <0.0001), mononuclear cells x 108/kg (0.55, range 0.20-1.4, vs 0.41, range 0.15-0.76, P <0.0001) and CFU-GM/ml (310, range 10-5500, vs 80, range 10-3800, P = 0.008), with lower volumes of blood collected (17.5 ml/kg, range 8-31 vs 21.0, range 15-30, P = 0.0001). Hematological recovery was faster in patients who received pre-treated BM (median time to PMN > 0.5 x 109/l and to platelets > 20 x 109/1 was 12, range 10-14, and 13, range 10-18, days, respectively) than in those autotransplanted with steady-state BM (median time to PMN > 0.5 x 109/l and to platelets > 20 x 109/l 13, range 10-18 and 14, range 10-20 days, respectively, P = 0.004 and P = 0.01). Transfusional requirement was significantly different and patients of the G-CSF group needed shorter hospitalization (17 days, range 12-24, vs 20 days, range 14-32; P = 0.02). These data suggest that treating patients with G-CSF before BM harvest improves the quality of the harvest and accelerates engraftment and hematological recovery.

Original languageEnglish
Pages (from-to)757-761
Number of pages5
JournalBone Marrow Transplantation
Volume24
Issue number7
Publication statusPublished - 1999

Keywords

  • ABMT
  • Bone marrow
  • Engraftment
  • G-CSF

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Damiani, D., Grimaz, S., Infanti, L., Sperotto, A., Silvestri, F., Geromin, A., Cerno, M., Savignano, C., Michieli, M., Skert, C., Fanin, R., & Baccarani, M. (1999). Autologous bone marrow transplantation in non-Hodgkin's lymphoma patients: Effect of a brief course of G-CSF on harvest and recovery. Bone Marrow Transplantation, 24(7), 757-761.