Autologous Chondrocytes in a Hyaluronic Acid Scaffold

Maurilio Marcacci, Elizaveta Kon, Stefano Zaffagnini, Francesco Iacono, Giuseppe Filardo, Marco Delcogliano

Research output: Contribution to journalArticlepeer-review


Articular cartilage lesions, with their inherent limited healing potential, remain a challenging problem for orthopedic surgeons. Various techniques, both palliative and reparative, have been used to treat this pathology with variable success rates. In recent years, however, regenerative techniques, such as autologous chondrocyte implantation, have emerged as possible solutions for the treatment of chondral knee lesions. The use of classic autologous chondrocyte implantation (first generation) has been associated with several limitations. To address these problems, tissue-engineering techniques have been developed. We selected a biodegradable, biocompatible, hyaluronian-based scaffold for cell proliferation. This matrix autologous chondrocyte transplantation procedure avoids the use of periosteal flap, simplifies the surgical procedure, and can be performed using an arthroscopic procedure. Thus, the surgical morbidity and the recovery time for the patient are extremely reduced with no complications related to the periosteal flap. The short- to medium-term follow-up clinical and histological results are encouraging.

Original languageEnglish
Pages (from-to)266-270
Number of pages5
JournalOperative Techniques in Orthopaedics
Issue number4
Publication statusPublished - Oct 2006


  • arthroscopy
  • cartilage
  • cell therapy
  • chondrocyte transplantation
  • hyaluronian
  • scaffold

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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