Autologous fat transfer after breast cancer surgery: An exact-matching study on the long-term oncological safety

Luca Sorrentino, Lea Regolo, Elisabetta Scoccia, Gianfranco Petrolo, Daniela Bossi, Sara Albasini, Annalisa Caruso, Renzo Vanna, Carlo Morasso, Serena Mazzucchelli, Marta Truffi, Fabio Corsi

Research output: Contribution to journalArticlepeer-review

Abstract

INTRODUCTION: Autologous fat transfer (AFT) is widely adopted for breast reconstruction, but its long-term oncologic safety is still not clearly established. The aim of the present study was to compare the 10-year loco-regional recurrence (LRR)-free and distant metastases (DM)-free survival probabilities in AFT vs. control patients, also evaluating the impact of AFT in different intrinsic molecular subtypes of breast cancer.

MATERIALS AND METHODS: 464 AFT patients were exactly matched with a cohort of 3100 control patients treated between 2007 and 2017. A multivariate survival analysis was performed accounting for all variables related to LRR and DM, including adjuvant/neoadjuvant treatments. End-points were analyzed both overall and in each molecular subtype.

RESULTS: LRR occurred in 6.4% of AFT and in 5.0% of control patients (p = 0.42), while DM were observed respectively in 7.7% and 5.4% of cases (p = 0.20). AFT showed no effect on the 10-year LRR-free survival probability (adjusted HR 0.87, 95%CI 0.43-1.76, p = 0.69) or the 10-year DM-free survival probability (adjusted HR 0.82, 95%CI 0.43-1.57, p = 0.55). Luminal A patients treated by AFT showed a decreased LRR-free survival probability (HR 2.38, 95%CI 0.91-6.17, Log-Rank p = 0.07), which was significantly lower than controls after 80 months (Log-Rank p = 0.02). No differences in the 10-year event-free survival probability were found in Luminal B, HER2-positive or triple-negative patients.

CONCLUSION: AFT does not increase breast cancer recurrence, with the possible exception of late LRRs for Luminal A patients, but further clinical and preclinical data are required to better clarify this data. The use of AFT should not be discouraged.

Original languageEnglish
Pages (from-to)1827-1834
Number of pages8
JournalEuropean Journal of Surgical Oncology
Volume45
Issue number10
DOIs
Publication statusPublished - Oct 2019

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