Autologous fat transplantation in patients with breast cancer: "silencing" or "fueling" cancer recurrence?

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Abstract

Lipotransfer can be considered a technical revolution in plastic surgery and widely performed for esthetic surgery. Recently the lipofilling has been indicated in breast reconstruction and deformity correction after breast conservative treatment. However, there is lack of understanding concerning the interactions between the potential tumor beds and the lipoaspirates grafts. Current literature underlines the efficacy of the technique as well as its safety. Nevertheless, many experimental studies provide data on the endocrine, paracrine, and autocrine activities of the transplanted fat tissues. Adipocyte, pre-adipocyte and progenitor cell secretions can stimulate angiogenesis and cell growth. The "tumor-stroma interaction" can potentially induce cancer reappearance by "fueling" dormant breast cancer cells in tumor bed. There is lack of translational research that proves this concern in clinical aspect. No study on the effects of lipotransfer on human cancer breast cells in vivo is available. We provide direct and indirect effects of lipotransfer in breast cancer patients, highlighting pro and con related issues. To confirm the safety of lipotransfer in breast cancer patients we need clinical studies with control group based on long term follow up.

Original languageEnglish
Pages (from-to)351-357
Number of pages7
JournalBreast
Volume20
Issue number4
DOIs
Publication statusPublished - Aug 2011

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Autologous Transplantation
Fats
Breast Neoplasms
Recurrence
Plastic Surgery
Adipocytes
Neoplasms
Safety
Translational Medical Research
Mammaplasty
Breast
Stem Cells
Transplants
Control Groups
Growth

Keywords

  • Adipocyte
  • Adipokines
  • Breast cancer
  • Breast reconstruction
  • Lipofilling
  • Plastic surgery

ASJC Scopus subject areas

  • Surgery

Cite this

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title = "Autologous fat transplantation in patients with breast cancer: {"}silencing{"} or {"}fueling{"} cancer recurrence?",
abstract = "Lipotransfer can be considered a technical revolution in plastic surgery and widely performed for esthetic surgery. Recently the lipofilling has been indicated in breast reconstruction and deformity correction after breast conservative treatment. However, there is lack of understanding concerning the interactions between the potential tumor beds and the lipoaspirates grafts. Current literature underlines the efficacy of the technique as well as its safety. Nevertheless, many experimental studies provide data on the endocrine, paracrine, and autocrine activities of the transplanted fat tissues. Adipocyte, pre-adipocyte and progenitor cell secretions can stimulate angiogenesis and cell growth. The {"}tumor-stroma interaction{"} can potentially induce cancer reappearance by {"}fueling{"} dormant breast cancer cells in tumor bed. There is lack of translational research that proves this concern in clinical aspect. No study on the effects of lipotransfer on human cancer breast cells in vivo is available. We provide direct and indirect effects of lipotransfer in breast cancer patients, highlighting pro and con related issues. To confirm the safety of lipotransfer in breast cancer patients we need clinical studies with control group based on long term follow up.",
keywords = "Adipocyte, Adipokines, Breast cancer, Breast reconstruction, Lipofilling, Plastic surgery",
author = "Visnu Lohsiriwat and Giuseppe Curigliano and Mario Rietjens and Aron Goldhirsch and Petit, {Jean Yves}",
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T2 - "silencing" or "fueling" cancer recurrence?

AU - Lohsiriwat, Visnu

AU - Curigliano, Giuseppe

AU - Rietjens, Mario

AU - Goldhirsch, Aron

AU - Petit, Jean Yves

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Y1 - 2011/8

N2 - Lipotransfer can be considered a technical revolution in plastic surgery and widely performed for esthetic surgery. Recently the lipofilling has been indicated in breast reconstruction and deformity correction after breast conservative treatment. However, there is lack of understanding concerning the interactions between the potential tumor beds and the lipoaspirates grafts. Current literature underlines the efficacy of the technique as well as its safety. Nevertheless, many experimental studies provide data on the endocrine, paracrine, and autocrine activities of the transplanted fat tissues. Adipocyte, pre-adipocyte and progenitor cell secretions can stimulate angiogenesis and cell growth. The "tumor-stroma interaction" can potentially induce cancer reappearance by "fueling" dormant breast cancer cells in tumor bed. There is lack of translational research that proves this concern in clinical aspect. No study on the effects of lipotransfer on human cancer breast cells in vivo is available. We provide direct and indirect effects of lipotransfer in breast cancer patients, highlighting pro and con related issues. To confirm the safety of lipotransfer in breast cancer patients we need clinical studies with control group based on long term follow up.

AB - Lipotransfer can be considered a technical revolution in plastic surgery and widely performed for esthetic surgery. Recently the lipofilling has been indicated in breast reconstruction and deformity correction after breast conservative treatment. However, there is lack of understanding concerning the interactions between the potential tumor beds and the lipoaspirates grafts. Current literature underlines the efficacy of the technique as well as its safety. Nevertheless, many experimental studies provide data on the endocrine, paracrine, and autocrine activities of the transplanted fat tissues. Adipocyte, pre-adipocyte and progenitor cell secretions can stimulate angiogenesis and cell growth. The "tumor-stroma interaction" can potentially induce cancer reappearance by "fueling" dormant breast cancer cells in tumor bed. There is lack of translational research that proves this concern in clinical aspect. No study on the effects of lipotransfer on human cancer breast cells in vivo is available. We provide direct and indirect effects of lipotransfer in breast cancer patients, highlighting pro and con related issues. To confirm the safety of lipotransfer in breast cancer patients we need clinical studies with control group based on long term follow up.

KW - Adipocyte

KW - Adipokines

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KW - Breast reconstruction

KW - Lipofilling

KW - Plastic surgery

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