Autologous haematopoietic stem-cell transplantation in multiple sclerosis: Benefits and risks

E. Capello, L. Vuolo, F. Gualandi, M. T. Van Lint, L. Roccatagliata, L. Bonzano, M. Pardini, A. Uccelli, Gianluigi Mancardi

Research output: Contribution to journalArticlepeer-review

Abstract

Autologous haematopoietic stem-cell transplantation has been evaluated over the last years as a possible new therapeutic strategy in severe forms of multiple sclerosis unresponsive to the approved therapies. Up to now, more than 400 patients have been treated and numerous are the phase I and phase II studies which addressed the feasibility of this treatment, the efficacy, side effects and transplant-related mortality. The clinical response is strongly related to the intensity of the conditioning regimen utilized as well as to the phase of the disease course in which the therapy is carried out. Rapidly evolving multiple sclerosis with a relapsing-remitting clinical course and MRI signs of activity are the cases that can take more advantage. The risk of mortality, which dropped in the last years to 2-3%, is still the main problem of this powerful therapy.

Original languageEnglish
JournalNeurological Sciences
Volume30
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 2009

Keywords

  • Autologous stem-cell transplantation
  • Intense immunosuppression in multiple sclerosis
  • Malignant forms of multiple sclerosis
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

Fingerprint Dive into the research topics of 'Autologous haematopoietic stem-cell transplantation in multiple sclerosis: Benefits and risks'. Together they form a unique fingerprint.

Cite this