Autologous haematopoietic stem cell transplantation without CD34 + cell selection in refractory Crohn's disease

Andrea Cassinotti, C. Annaloro, S. Ardizzone, F. Onida, A. Della Volpe, M. Clerici, P. Usardi, S. Greco, G. Maconi, G. Bianchi Porro, G. Lambertenghi Deliliers

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Autologous haematopoietic stem cell transplantation (HSCT) with CD34+ cell selection has recently been used in the treatment of refractory Crohn's disease, showing good safety and promising efficacy. We investigated the safety and efficacy of HSCT with unselected peripheral blood stem cells (PBSCs) in moderate-severe refractory Crohn's disease. Patients: Four patients (three male, one female; age range 26-45 years) with active moderate-severe Crohn's disease (median Crohn's Disease Activity Index (CDAI) 319, range 272-345), refractory or intolerant to multiple drugs including infliximab, were enrolled. Interventions: Unselected PBSCs were collected after mobilisation with cyclophosphamide (CTX) 1.5 g/m2 and granulocyte-colony stimulating factor (G-CSF) 10 μg/kg. The conditioning regimen included CTX 50 mg/kg on days -5 to -2 and rabbit anti-thymocyte globulin (ATG) 2.5 mg/kg on days -4 to -2. Main outcome measures: Primary endpoints were toxicity and clinical remission (CDAI

Original languageEnglish
Pages (from-to)211-217
Number of pages7
JournalGut
Volume57
Issue number2
DOIs
Publication statusPublished - Feb 2008

ASJC Scopus subject areas

  • Gastroenterology

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