Autologous islet transplantation in patients requiring pancreatectomy for neoplasm

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Abstract

Autologous islet cell transplantation is a procedure performed to prevent or reduce the severity of diabetes after pancreatic resection. Autologous islet cell transplantation is being used almost exclusively in patients undergoing pancreatectomy because of painful, chronic pancreatitis, or multiple recurrent episodes of pancreatitis that is not controlled by standard medical and surgical treatments. Here, we discuss the possibility of extending the clinical indications for this treatment on the basis of our experience in patients undergoing pancreatic surgery for both nonmalignant and malignant diseases, including patients undergoing completion pancreatectomy because of anastomosis leakage after pancreaticoduodenectomy and those with pancreatic anastomosis deemed at high risk for failure.

Original languageEnglish
Article number512
JournalCurrent Diabetes Reports
Volume14
Issue number8
DOIs
Publication statusPublished - 2014

Fingerprint

Islets of Langerhans Transplantation
Pancreatectomy
Autologous Transplantation
Cell Transplantation
Islets of Langerhans
Neoplasms
Pancreaticoduodenectomy
Chronic Pancreatitis
Pancreatitis
Therapeutics

Keywords

  • Islet autotransplantation
  • Neoplasm
  • Pancreatectomy
  • Pancreatic cancer
  • Pancreatogenic diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Medicine(all)

Cite this

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AB - Autologous islet cell transplantation is a procedure performed to prevent or reduce the severity of diabetes after pancreatic resection. Autologous islet cell transplantation is being used almost exclusively in patients undergoing pancreatectomy because of painful, chronic pancreatitis, or multiple recurrent episodes of pancreatitis that is not controlled by standard medical and surgical treatments. Here, we discuss the possibility of extending the clinical indications for this treatment on the basis of our experience in patients undergoing pancreatic surgery for both nonmalignant and malignant diseases, including patients undergoing completion pancreatectomy because of anastomosis leakage after pancreaticoduodenectomy and those with pancreatic anastomosis deemed at high risk for failure.

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