Autotrapianto di linfociti come nuova opzione terapeutica nell'artrite cronica giovanile intrattabile

Translated title of the contribution: Autologous lymphocyte transplantation as a new therapeutic option in intractable juvenile chronic arthritis

S. Parco, G. Bruno, R. Giorgini, M. Rabusin, M. Andolina, L. Lepore

Research output: Contribution to journalArticle

Abstract

There is clinical evidence that allogeneic bone marrow transplantation can cure autoimmune diseases and that autologous bone marrow transplantation can induce a long lasting remission. We submitted to this procedure three patients with intractable juvenile chronic arthritis. The aim of our procedure was to achieve an immune tolerance by incubating the patient's lymphocytes with vincristine and methylprednisolone without T depletion. We used an immunosuppressive therapy with cyclophosphamide at a lower dosage than the traditional autologous transplantation. All the patients achieved a profound clinical remission associated with a normalization of laboratory inflammatory indexes. One patient relapsed after 8 months and the others two are in partial remission after 5 months. In conclusion, the autologous BMT is a rational therapeutic option, able to induce a profound remission in severe, refractory autoimmune diseases. We would stress that our procedure was well tolerated by the patients and has negligible risks.

Translated title of the contributionAutologous lymphocyte transplantation as a new therapeutic option in intractable juvenile chronic arthritis
Original languageItalian
Pages (from-to)207-211
Number of pages5
JournalTrasfusione del Sangue
Volume44
Issue number4
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Hematology
  • Immunology and Allergy

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    Parco, S., Bruno, G., Giorgini, R., Rabusin, M., Andolina, M., & Lepore, L. (1999). Autotrapianto di linfociti come nuova opzione terapeutica nell'artrite cronica giovanile intrattabile. Trasfusione del Sangue, 44(4), 207-211.