Autologous marrow stem cell transplantation for severe systemic lupus erythematosus of long duration

A. M. Marmont, M. T. Van Lint, F. Gualandi, A. Bacigalupo

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

A 46 year woman with severe long-lasting SLE received an autologous bone marrow transplantation utilising CD34+ haematopoietic progenitors following a 3 log T-lymphocyte depletion. The immunosuppressive regimen (conditioning) consisted of 15 mg/kg Thiotepa followed by 100 mg/kg of cyclophosphamide over 2 d. Granulocytic recovery was aided by G-CSF. The post-transplant course was uneventful, and a good clinical and immunologic remission (ANA negativisation) was achieved. This is the first case of SLE having received an autologous progenitor cell transplant for the autoimmune disease by itself, unaccompanied by a haematologic condition requiring transplantation. The potential, advantages and limits of this procedure, which are currently being explored worldwide, are briefly discussed.

Original languageEnglish
Pages (from-to)545-548
Number of pages4
JournalLupus
Volume6
Issue number6
Publication statusPublished - 1997

Fingerprint

Stem Cell Transplantation
Systemic Lupus Erythematosus
Bone Marrow
Lymphocyte Depletion
Thiotepa
Transplants
Autologous Transplantation
Granulocyte Colony-Stimulating Factor
Immunosuppressive Agents
Bone Marrow Transplantation
Cyclophosphamide
Autoimmune Diseases
Stem Cells
Transplantation
T-Lymphocytes

Keywords

  • Autologous marrow transplantation (ABMT)
  • Systemic lupus erythematosus (SLE)

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Autologous marrow stem cell transplantation for severe systemic lupus erythematosus of long duration. / Marmont, A. M.; Van Lint, M. T.; Gualandi, F.; Bacigalupo, A.

In: Lupus, Vol. 6, No. 6, 1997, p. 545-548.

Research output: Contribution to journalArticle

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