Abstract
Human immunodeficiency virus type 2 (HIV-2) has been reported to be less pathogenic than HIV-1. We have investigated the capacity of sera from nine HIV-2-infected individuals to neutralize their own autologous virus. All nine HIV-2-infected individuals neutralized autologous virus with titers ranging between 20 and 320. In contrast, we have previously reported that most HIV-1-infected individuals lack such antibodies. The difference between HIV-1 and HIV-2 infection was statistically significant (P <0.0002, Pearson test) and the difference in neutralizing antibody prevalence may explain the faster disease progression in HIV-1-infected individuals than in HIV-2-infected individuals.
Original language | English |
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Pages (from-to) | 528-530 |
Number of pages | 3 |
Journal | Virology |
Volume | 193 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1993 |
ASJC Scopus subject areas
- Virology
- Infectious Diseases