Autologous neutralizing antibodies prevail in HIV-2 but not in HIV-1 infection

E. Bjorling, G. Scarlatti, A. Von Gegerfelt, J. Albert, G. Biberfeld, F. Chiodi, E. Norrby, E. M. Fenyo

Research output: Contribution to journalArticlepeer-review

Abstract

Human immunodeficiency virus type 2 (HIV-2) has been reported to be less pathogenic than HIV-1. We have investigated the capacity of sera from nine HIV-2-infected individuals to neutralize their own autologous virus. All nine HIV-2-infected individuals neutralized autologous virus with titers ranging between 20 and 320. In contrast, we have previously reported that most HIV-1-infected individuals lack such antibodies. The difference between HIV-1 and HIV-2 infection was statistically significant (P <0.0002, Pearson test) and the difference in neutralizing antibody prevalence may explain the faster disease progression in HIV-1-infected individuals than in HIV-2-infected individuals.

Original languageEnglish
Pages (from-to)528-530
Number of pages3
JournalVirology
Volume193
Issue number1
DOIs
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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