Autologous serum skin test reactivity in patients with non-allergic asthma

A. Tedeschi, A. L. Comi, M. Lorini, C. Tosini, A. Miadonna

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Inflammatory alterations of respiratory airways have been found in patients with non-allergic asthma, but the triggering event has not been defined. An autoimmune activation of inflammatory cells has been hypothesized. Objective: To evaluate whether histamine-releasing factors are present in sera from non-allergic asthmatics. Methods: Twenty-four patients with non-allergic asthma underwent in vivo autologous serum skin test (ASST) and in vitro basophil histamine release assay using autologous basophils as well as basophils from normal donors. Twenty-seven subjects with respiratory allergy and three normal subjects were chosen as control. Results: ASST was positive in 14/24 non-allergic asthmatics (58%) whereas it was negative in all 30 control subjects (P

Original languageEnglish
Pages (from-to)849-853
Number of pages5
JournalClinical and Experimental Allergy
Volume35
Issue number7
DOIs
Publication statusPublished - Jul 2005

Keywords

  • Autologous serum skin test
  • Basophils
  • Histamine-releasing factors
  • Mast cells
  • Non-allergic asthma

ASJC Scopus subject areas

  • Immunology

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