Autologous serum skin test reactivity in patients with non-allergic asthma

A. Tedeschi, A. L. Comi, M. Lorini, C. Tosini, A. Miadonna

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Inflammatory alterations of respiratory airways have been found in patients with non-allergic asthma, but the triggering event has not been defined. An autoimmune activation of inflammatory cells has been hypothesized. Objective: To evaluate whether histamine-releasing factors are present in sera from non-allergic asthmatics. Methods: Twenty-four patients with non-allergic asthma underwent in vivo autologous serum skin test (ASST) and in vitro basophil histamine release assay using autologous basophils as well as basophils from normal donors. Twenty-seven subjects with respiratory allergy and three normal subjects were chosen as control. Results: ASST was positive in 14/24 non-allergic asthmatics (58%) whereas it was negative in all 30 control subjects (P

Original languageEnglish
Pages (from-to)849-853
Number of pages5
JournalClinical and Experimental Allergy
Volume35
Issue number7
DOIs
Publication statusPublished - Jul 2005

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Basophils
Skin Tests
Asthma
Serum
Histamine Release
Hypersensitivity
Tissue Donors

Keywords

  • Autologous serum skin test
  • Basophils
  • Histamine-releasing factors
  • Mast cells
  • Non-allergic asthma

ASJC Scopus subject areas

  • Immunology

Cite this

Autologous serum skin test reactivity in patients with non-allergic asthma. / Tedeschi, A.; Comi, A. L.; Lorini, M.; Tosini, C.; Miadonna, A.

In: Clinical and Experimental Allergy, Vol. 35, No. 7, 07.2005, p. 849-853.

Research output: Contribution to journalArticle

Tedeschi, A. ; Comi, A. L. ; Lorini, M. ; Tosini, C. ; Miadonna, A. / Autologous serum skin test reactivity in patients with non-allergic asthma. In: Clinical and Experimental Allergy. 2005 ; Vol. 35, No. 7. pp. 849-853.
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