Autologous stem cell transplantation for HIV-associated lymphoma in the antiretroviral and rituximab era: a retrospective study by the EBMT Lymphoma Working Party

Kai Hübel, Alessandro Re, Ariane Boumendil, Herve Finel, Marcus Hentrich, Stephen Robinson, Christoph Wyen, Mariagrazia Michieli, Edward Kanfer, Jose Luis Diez-Martin, Pascual Balsalobre, Laure Vincent, Wilfried Schroyens, Josep Maria Ribera Santasusana, Nicolaus Kröger, Xaver Schiel, Kate Cwynarski, Albert Esquirol, Aida Botelho Sousa, Chiara CattaneoSilvia Montoto, Peter Dreger

Research output: Contribution to journalArticlepeer-review

Abstract

The present study aimed at describing the outcome of patients with HIV-associated lymphomas following autologous hematopoietic stem cell transplantation (autoHCT) in the rituximab and combined antiretroviral therapy (cART) era. Eligible for this retrospective study were HIV-positive patients with lymphoma who received autoHCT between 2007 and 2013. A total of 118 patients were included with a median age of 45 years (range 24–66). Underlying diagnoses were diffuse large B cell lymphoma in 47%, Hodgkin lymphoma in 24%, Burkitt lymphoma in 18%, and plasmablastic lymphoma in 7% of patients. Disease status at autoHCT was complete remission in 44%, partial remission (PR) in 38%, and less than PR in 18% of the patients. With a median follow-up of 4 years, 3-year non-relapse mortality, incidence of relapse, progression-free survival (PFS) and overall survival (OS) were 10%, 27%, 63% and 66%, respectively. By multivariate analysis, disease status less than PR but not CD4+ cell count at the time of autoHCT was a significant predictor of unfavorable PFS and OS. In conclusion, in the era of cART and chemoimmunotherapy, the outcome of autoHCT for HIV-related lymphoma is driven by lymphoma-dependent risk factors rather than by characteristics of the HIV infection.

Original languageEnglish
Pages (from-to)1625-1631
Number of pages7
JournalBone Marrow Transplantation
Volume54
Issue number10
DOIs
Publication statusPublished - Oct 1 2019

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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