Autologous stem cell transplantation for severe autoimmune diseases: A 10-year experience

F. Gualandi, B. Bruno, M. T. Van Lint, S. Luchetti, A. Uccelli, E. Capello, G. L. Mancardi, A. Bacigalupo, A. Marmont

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The first autologous hematopoietic stem cell transplantation in Europe for a patient with severe refractory systemic lupus erythematosus (SLE) was performed in Genoa in 1996. Since then, 32 patients with a wide spectrum of autoimmune diseases (ADs) received autologous transplants, 22 of them with multiple sclerosis (MS). There were no fatal adverse events. All patients had complete or very good partial remissions, but relapses were frequent, especially in SLE, though never as aggressive as pretransplant. The mechanism of action of this intervention remains not completely understood, as briefly discussed here.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages455-464
Number of pages10
Volume1110
DOIs
Publication statusPublished - Sep 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1110
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • Behçet's disease
  • BMT/SCT
  • Multiple sclerosis
  • SADs
  • Severe autoimmune diseases
  • Stem cell transplant
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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