Autologous stem cell transplantation for severe autoimmune diseases: A 10-year experience

F. Gualandi, B. Bruno, M. T. Van Lint, S. Luchetti, A. Uccelli, E. Capello, G. L. Mancardi, A. Bacigalupo, A. Marmont

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The first autologous hematopoietic stem cell transplantation in Europe for a patient with severe refractory systemic lupus erythematosus (SLE) was performed in Genoa in 1996. Since then, 32 patients with a wide spectrum of autoimmune diseases (ADs) received autologous transplants, 22 of them with multiple sclerosis (MS). There were no fatal adverse events. All patients had complete or very good partial remissions, but relapses were frequent, especially in SLE, though never as aggressive as pretransplant. The mechanism of action of this intervention remains not completely understood, as briefly discussed here.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages455-464
Number of pages10
Volume1110
DOIs
Publication statusPublished - Sep 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1110
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

antineoplaston A10
Autografts
Stem Cell Transplantation
Stem cells
Refractory materials
Autoimmune Diseases
Systemic Lupus Erythematosus
Hematopoietic Stem Cell Transplantation
Multiple Sclerosis
Recurrence

Keywords

  • Behçet's disease
  • BMT/SCT
  • Multiple sclerosis
  • SADs
  • Severe autoimmune diseases
  • Stem cell transplant
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Gualandi, F., Bruno, B., Van Lint, M. T., Luchetti, S., Uccelli, A., Capello, E., ... Marmont, A. (2007). Autologous stem cell transplantation for severe autoimmune diseases: A 10-year experience. In Annals of the New York Academy of Sciences (Vol. 1110, pp. 455-464). (Annals of the New York Academy of Sciences; Vol. 1110). https://doi.org/10.1196/annals.1423.048

Autologous stem cell transplantation for severe autoimmune diseases : A 10-year experience. / Gualandi, F.; Bruno, B.; Van Lint, M. T.; Luchetti, S.; Uccelli, A.; Capello, E.; Mancardi, G. L.; Bacigalupo, A.; Marmont, A.

Annals of the New York Academy of Sciences. Vol. 1110 2007. p. 455-464 (Annals of the New York Academy of Sciences; Vol. 1110).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gualandi, F, Bruno, B, Van Lint, MT, Luchetti, S, Uccelli, A, Capello, E, Mancardi, GL, Bacigalupo, A & Marmont, A 2007, Autologous stem cell transplantation for severe autoimmune diseases: A 10-year experience. in Annals of the New York Academy of Sciences. vol. 1110, Annals of the New York Academy of Sciences, vol. 1110, pp. 455-464. https://doi.org/10.1196/annals.1423.048
Gualandi F, Bruno B, Van Lint MT, Luchetti S, Uccelli A, Capello E et al. Autologous stem cell transplantation for severe autoimmune diseases: A 10-year experience. In Annals of the New York Academy of Sciences. Vol. 1110. 2007. p. 455-464. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1423.048
Gualandi, F. ; Bruno, B. ; Van Lint, M. T. ; Luchetti, S. ; Uccelli, A. ; Capello, E. ; Mancardi, G. L. ; Bacigalupo, A. ; Marmont, A. / Autologous stem cell transplantation for severe autoimmune diseases : A 10-year experience. Annals of the New York Academy of Sciences. Vol. 1110 2007. pp. 455-464 (Annals of the New York Academy of Sciences).
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