Autologous unpurged bone marrow transplantation for acute non-lymphoblastic leukaemia in first complete remission

A. M. Carella, E. Gaozza, G. Santini, M. Martinengo, E. Pungolino, G. Piatti, A. Congiu, S. Nati, P. Carlier, D. Giordano, R. Cerri, M. Risso, S. Miceli, M. R. Raffo, D. Scarpati, R. Corvo, P. Franzone, V. Vitale, A. R. Vimercati

Research output: Contribution to journalArticle

Abstract

Twenty-five patients with acute non-lymphoblastic leukemia (ANLL) in first complete remission underwent autologous bone marrow transplantation (ABMT) between March 1984 and March 1988. The high-dose therapy employed included cyclophosphamide followed by total body irradiation (10 Gy), administered as a single dose. The median time from complete remission to ABMT was 5 months (range 2-9 months). Thirteen (52%) patients remain in complete remission 10-51 months (median 25 months) after ABMT and 14-60 months (median 32 months) after achieving complete remission. Causes of death were recurrent leukemia (five patients), parenchymal toxicities (acute respiratory distress syndrome, veno-occlusive disease) (three patients), cerebral haemorrhage (one patient), cerebral aspergillosis (one patient) and viral hepatitis (one patient). Six patients relapsed at a median of 5 months after ABMT (range 4-10 months). In conclusion, this study has resulted in survival data comparable to those of other institutions and the best reported outcomes of conventional chemotherapy.

Original languageEnglish
Pages (from-to)537-541
Number of pages5
JournalBone Marrow Transplantation
Volume3
Issue number6
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Carella, A. M., Gaozza, E., Santini, G., Martinengo, M., Pungolino, E., Piatti, G., Congiu, A., Nati, S., Carlier, P., Giordano, D., Cerri, R., Risso, M., Miceli, S., Raffo, M. R., Scarpati, D., Corvo, R., Franzone, P., Vitale, V., & Vimercati, A. R. (1988). Autologous unpurged bone marrow transplantation for acute non-lymphoblastic leukaemia in first complete remission. Bone Marrow Transplantation, 3(6), 537-541.