Autologous unpurged bone marrow transplantation for acute non lymphoblastic leukemia in first remission

Angelo M. Carella, Sandro Nati, Paolo Carlier, Daniela Pierluigi, Domenico Giordano, Angela Congiu, Gino Santini, Daniele Scarpati, Salvina Barra, Renzo Corvo, Vito Vitale, Maria R. Raffo, Raffaella Cerri, Marco Risso, Mauro Spriano, Renato Vimercati, Ester Pungolino, Andrea Bacigalupo, Eugenio Damasio

Research output: Contribution to journalArticlepeer-review

Abstract

Forty consecutive adult patients under the age of 50 with acute non-lymphoblastic leukemia (ANLL) in first complete remission, underwent autologous bone marrow transplantation (ABMT) between March 1984 and April 1990. The conditioning regimen employed included cyclophosphamide and total body irradiation, followed by the administration of unpurged ABMT. The median time from diagnosis to transplant was 7 months (3-15 months), and the median time from complete remission to ABMT was 4 months (range 3-9 months). Twenty-two (51%) patients remain in complete remission 6-81 months (median 24 months) after ABMT. The causes of death were, recurrent leukemia (11 patients), parenchymal toxicities such as acute respiratory distress syndrome and veno-occlusive disease (3 patients), hemorrhage (2 patients) and infection (2 patients). Eleven patients relapsed after 3-12 months (median 5 months). This study has produced survival data comparable to those of other institutions employing TBI for either allo or autotransplants.

Original languageEnglish
Pages (from-to)43-47
Number of pages5
JournalLeukemia and Lymphoma
Volume5
Issue number1
DOIs
Publication statusPublished - 1991

Keywords

  • ANLL
  • Autologous BMT

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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