Automated production of copper radioisotopes and preparation of high specific activity [64Cu]Cu-ATSM for PET studies

Mario Matarrese, Paolo Bedeschi, Roberto Scardaoni, Francesco Sudati, Annarita Savi, Annalisa Pepe, Valeria Masiello, Sergio Todde, Luigi Gianolli, Cristina Messa, Ferruccio Fazio

Research output: Contribution to journalArticle

Abstract

60Cu and 64Cu are useful radioisotopes for positron emission tomography (PET) radiopharmaceuticals and may be used for the preparation of promising agents for diagnosis and radiotherapy. In this study, the production and purification of 60/64Cu starting from 60/64Ni using a new automated system, namely Alceo, is described. A dynamic process for electrodeposition and dissolution of 60/64Ni/60/64Cu was developed. Preliminary production yields of 60Cu and 64Cu were 400 and 300 mCi, respectively. 64Cu was used to radiolabel the hypoxia detection tracer ATSM with a specific activity of 2.2±1.3 Ci/μmol.

Original languageEnglish
Pages (from-to)5-13
Number of pages9
JournalApplied Radiation and Isotopes
Volume68
Issue number1
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Cu
  • Cu
  • Alceo
  • PET
  • Radionuclide production
  • Solid target

ASJC Scopus subject areas

  • Radiation

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    Matarrese, M., Bedeschi, P., Scardaoni, R., Sudati, F., Savi, A., Pepe, A., Masiello, V., Todde, S., Gianolli, L., Messa, C., & Fazio, F. (2010). Automated production of copper radioisotopes and preparation of high specific activity [64Cu]Cu-ATSM for PET studies. Applied Radiation and Isotopes, 68(1), 5-13. https://doi.org/10.1016/j.apradiso.2009.08.010