Automated production of copper radioisotopes and preparation of high specific activity [64Cu]Cu-ATSM for PET studies

Mario Matarrese; Paolo Bedeschi; Roberto Scardaoni; Francesco Sudati; Annarita Savi; Annalisa Pepe; Valeria Masiello; Sergio Todde; Luigi Gianolli; Cristina Messa; Ferruccio Fazio

doi:10.1016/j.apradiso.2009.08.010

Automated production of copper radioisotopes and preparation of high specific activity [⁶⁴Cu]Cu-ATSM for PET studies

Mario Matarrese, Paolo Bedeschi, Roberto Scardaoni, Francesco Sudati, Annarita Savi, Annalisa Pepe, Valeria Masiello, Sergio Todde, Luigi Gianolli, Cristina Messa, Ferruccio Fazio

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

⁶⁰Cu and ⁶⁴Cu are useful radioisotopes for positron emission tomography (PET) radiopharmaceuticals and may be used for the preparation of promising agents for diagnosis and radiotherapy. In this study, the production and purification of ^60/64Cu starting from ^60/64Ni using a new automated system, namely Alceo, is described. A dynamic process for electrodeposition and dissolution of ^60/64Ni/^60/64Cu was developed. Preliminary production yields of ⁶⁰Cu and ⁶⁴Cu were 400 and 300 mCi, respectively. ⁶⁴Cu was used to radiolabel the hypoxia detection tracer ATSM with a specific activity of 2.2±1.3 Ci/μmol.

Original language	English
Pages (from-to)	5-13
Number of pages	9
Journal	Applied Radiation and Isotopes
Volume	68
Issue number	1
DOIs	https://doi.org/10.1016/j.apradiso.2009.08.010
Publication status	Published - Jan 2010

Keywords

Cu
Cu
Alceo
PET
Radionuclide production
Solid target

ASJC Scopus subject areas

Radiation

Access to Document

10.1016/j.apradiso.2009.08.010

Cite this

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title = "Automated production of copper radioisotopes and preparation of high specific activity [64Cu]Cu-ATSM for PET studies",

abstract = " 60Cu and 64Cu are useful radioisotopes for positron emission tomography (PET) radiopharmaceuticals and may be used for the preparation of promising agents for diagnosis and radiotherapy. In this study, the production and purification of 60/64Cu starting from 60/64Ni using a new automated system, namely Alceo, is described. A dynamic process for electrodeposition and dissolution of 60/64Ni/60/64Cu was developed. Preliminary production yields of 60Cu and 64Cu were 400 and 300 mCi, respectively. 64Cu was used to radiolabel the hypoxia detection tracer ATSM with a specific activity of 2.2±1.3 Ci/μmol.",

keywords = "Cu, Cu, Alceo, PET, Radionuclide production, Solid target",

author = "Mario Matarrese and Paolo Bedeschi and Roberto Scardaoni and Francesco Sudati and Annarita Savi and Annalisa Pepe and Valeria Masiello and Sergio Todde and Luigi Gianolli and Cristina Messa and Ferruccio Fazio",

year = "2010",

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language = "English",

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T1 - Automated production of copper radioisotopes and preparation of high specific activity [64Cu]Cu-ATSM for PET studies

AU - Matarrese, Mario

AU - Bedeschi, Paolo

AU - Scardaoni, Roberto

AU - Sudati, Francesco

AU - Savi, Annarita

AU - Pepe, Annalisa

AU - Masiello, Valeria

AU - Todde, Sergio

AU - Gianolli, Luigi

AU - Messa, Cristina

AU - Fazio, Ferruccio

PY - 2010/1

Y1 - 2010/1

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AB - 60Cu and 64Cu are useful radioisotopes for positron emission tomography (PET) radiopharmaceuticals and may be used for the preparation of promising agents for diagnosis and radiotherapy. In this study, the production and purification of 60/64Cu starting from 60/64Ni using a new automated system, namely Alceo, is described. A dynamic process for electrodeposition and dissolution of 60/64Ni/60/64Cu was developed. Preliminary production yields of 60Cu and 64Cu were 400 and 300 mCi, respectively. 64Cu was used to radiolabel the hypoxia detection tracer ATSM with a specific activity of 2.2±1.3 Ci/μmol.

KW - Cu

KW - Alceo

KW - PET

KW - Radionuclide production

KW - Solid target

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