Automatic selection of arterial input function on dynamic contrast-enhanced MR images

Denis Peruzzo, Alessandra Bertoldo, Francesca Zanderigo, Claudio Cobelli

Research output: Contribution to journalArticlepeer-review


Dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI) data analysis requires the knowledge of the arterial input function (AIF) to quantify the cerebral blood flow (CBF), volume (CBV) and the mean transit time (MTT). AIF can be obtained either manually or using automatic algorithms. We present a method to derive the AIF on the middle cerebral artery (MCA). The algorithm draws a region of interest (ROI) where the MCA is located. Then, it uses a recursive cluster analysis on the ROI to select the arterial voxels. The algorithm had been compared on simulated data to literature state of art automatic algorithms and on clinical data to the manual procedure. On in silico data, our method allows to reconstruct the true AIF and it is less affected by partial volume effect bias than the other methods. In clinical data, automatic AIF provides CBF and MTT maps with a greater contrast level compared to manual AIF ones. Therefore, AIF obtained with the proposed method improves the estimate reliability and provides a quantitatively reliable physiological picture.

Original languageEnglish
JournalComputer Methods and Programs in Biomedicine
Issue number3
Publication statusPublished - Dec 2011


  • AIF
  • CBF
  • CBV
  • Contrast agents
  • MTT

ASJC Scopus subject areas

  • Computer Science Applications
  • Software
  • Health Informatics


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