Abstract
We compared four fully automated systems (Boehringer ES700, Tosoh AIA1200, Bayer Immunol, Mitsui Quartus) using 50 routine sera that included both euthyroid and pathological (with various degrees of hyper- or hypothyroidism) samples. The comparisons among systems by linear regression analysis yielded contradicting results, especially for fT4. Using the reference values of fT4 and TSH recommended from the manufacturers, the systems agreed completely in classification of patients in 32 cases; three systems agreed in seven cases, and two systems agreed in 10 cases; in one case, they completely disagreed. The agreement among the four systems we studied was high and would allow their introduction and use for routine thyroid screening. Comparison tests among fully automated systems for fT4 and TSH should not be determined only by linear regression statistical method, but additional functional validations must be performed.
| Original language | English |
|---|---|
| Pages (from-to) | 171-175 |
| Number of pages | 5 |
| Journal | Journal of Clinical Ligand Assay |
| Volume | 18 |
| Issue number | 3 |
| Publication status | Published - 1995 |
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Keywords
- automation
- discrepant values
- immunochemistry
- thyroid testing
ASJC Scopus subject areas
- Clinical Biochemistry
- Immunology
Cite this
Automation of thyroid screening : A critical comparison of four systems. / Banfi, G.; Pontillo, M.; Bonini, P.
In: Journal of Clinical Ligand Assay, Vol. 18, No. 3, 1995, p. 171-175.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Automation of thyroid screening
T2 - A critical comparison of four systems
AU - Banfi, G.
AU - Pontillo, M.
AU - Bonini, P.
PY - 1995
Y1 - 1995
N2 - We compared four fully automated systems (Boehringer ES700, Tosoh AIA1200, Bayer Immunol, Mitsui Quartus) using 50 routine sera that included both euthyroid and pathological (with various degrees of hyper- or hypothyroidism) samples. The comparisons among systems by linear regression analysis yielded contradicting results, especially for fT4. Using the reference values of fT4 and TSH recommended from the manufacturers, the systems agreed completely in classification of patients in 32 cases; three systems agreed in seven cases, and two systems agreed in 10 cases; in one case, they completely disagreed. The agreement among the four systems we studied was high and would allow their introduction and use for routine thyroid screening. Comparison tests among fully automated systems for fT4 and TSH should not be determined only by linear regression statistical method, but additional functional validations must be performed.
AB - We compared four fully automated systems (Boehringer ES700, Tosoh AIA1200, Bayer Immunol, Mitsui Quartus) using 50 routine sera that included both euthyroid and pathological (with various degrees of hyper- or hypothyroidism) samples. The comparisons among systems by linear regression analysis yielded contradicting results, especially for fT4. Using the reference values of fT4 and TSH recommended from the manufacturers, the systems agreed completely in classification of patients in 32 cases; three systems agreed in seven cases, and two systems agreed in 10 cases; in one case, they completely disagreed. The agreement among the four systems we studied was high and would allow their introduction and use for routine thyroid screening. Comparison tests among fully automated systems for fT4 and TSH should not be determined only by linear regression statistical method, but additional functional validations must be performed.
KW - automation
KW - discrepant values
KW - immunochemistry
KW - thyroid testing
UR - http://www.scopus.com/inward/record.url?scp=0028811101&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028811101&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0028811101
VL - 18
SP - 171
EP - 175
JO - Journal of Clinical Ligand Assay
JF - Journal of Clinical Ligand Assay
SN - 1081-1672
IS - 3
ER -