Autonomic and hormonal ictal changes in gelastic seizures from hypothalamic hamartomas

A. Cerullo, P. Tinuper, F. Provini, M. Contin, A. Rosati, C. Marini, P. Cortelli

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: We describe two patients with hypothalamic hamartoma and gelastic seizures. Methods: We performed ictal neurophysiological studies with polygraphic recordings of autonomic parameters and hormonal ictal plasma concentration measurements. Results: Ictal recordings showed a stereotyped modification of autonomic parameters: increase in blood pressure and heart rate, peripheral vasoconstriction and modification of respiratory activity. At seizure onset, the norepinephrine plasma level was high and epinephrine unchanged, whereas prolactin and adrenocorticotropic hormone were increased in both cases. Growth hormone and cortisol plasma concentrations in each patient showed a different response to seizures. Conclusions: These data provide evidence that gelastic seizures are accompanied by an abrupt sympathetic system activation, probably due to the direct paroxysmal activation of limbic and paralimbic structures or other autonomic centres of the hypothalamus and medulla.

Original languageEnglish
Pages (from-to)317-322
Number of pages6
JournalElectroencephalography and Clinical Neurophysiology
Volume107
Issue number5
DOIs
Publication statusPublished - Nov 1 1998

Keywords

  • Autonomic nervous system
  • Endocrine
  • Epilepsy
  • Gelastic seizure
  • Hypothalamic hamartoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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