Autonomic and renal effects of intravenous diazoxide. A study of the mechanisms of its hypotensive action in man

G. Leonetti, S. Grazi, A. Ligresti, S. Romano, A. Zanchetti

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Intravenous diazoxide produced an immediate marked hypotension in both mild and severe hypertensive patients. Depression of vasomotor reflexes, tested by the Valsalva overshoot, and of pressor responsiveness to noradrenaline was found only in the group of mild hypertensives. Decreased pressor reactivity to noradrenaline was not due to a nonspecific vascular effect of diazoxide, because pressor responsiveness to angiotensin was simultaneously increased. Renal tubular reabsorption of sodium and water was increased shortly after injection of diazoxide, and there was also a significant retention of potassium. Correlation studies suggest that interference with vasomotor reflexes, and with vascular responsiveness to the sympathetic transmitter, can account only in part for the hypotensive action of diazoxide. The possible rôles of water and electrolyte redistribution remain to be elucidated.

Original languageEnglish
Pages (from-to)206-215
Number of pages10
JournalEuropean Journal of Clinical Pharmacology
Volume2
Issue number4
DOIs
Publication statusPublished - Oct 1970

Fingerprint

Autonomic Agents
Diazoxide
Kidney
Blood Vessels
Reflex
Norepinephrine
Water
Angiotensins
Hypotension
Electrolytes
Potassium
Sodium
Injections

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

Autonomic and renal effects of intravenous diazoxide. A study of the mechanisms of its hypotensive action in man. / Leonetti, G.; Grazi, S.; Ligresti, A.; Romano, S.; Zanchetti, A.

In: European Journal of Clinical Pharmacology, Vol. 2, No. 4, 10.1970, p. 206-215.

Research output: Contribution to journalArticle

Leonetti, G. ; Grazi, S. ; Ligresti, A. ; Romano, S. ; Zanchetti, A. / Autonomic and renal effects of intravenous diazoxide. A study of the mechanisms of its hypotensive action in man. In: European Journal of Clinical Pharmacology. 1970 ; Vol. 2, No. 4. pp. 206-215.
@article{17ae0cd1ff8a48ef99fde7890644aae5,
title = "Autonomic and renal effects of intravenous diazoxide. A study of the mechanisms of its hypotensive action in man",
abstract = "Intravenous diazoxide produced an immediate marked hypotension in both mild and severe hypertensive patients. Depression of vasomotor reflexes, tested by the Valsalva overshoot, and of pressor responsiveness to noradrenaline was found only in the group of mild hypertensives. Decreased pressor reactivity to noradrenaline was not due to a nonspecific vascular effect of diazoxide, because pressor responsiveness to angiotensin was simultaneously increased. Renal tubular reabsorption of sodium and water was increased shortly after injection of diazoxide, and there was also a significant retention of potassium. Correlation studies suggest that interference with vasomotor reflexes, and with vascular responsiveness to the sympathetic transmitter, can account only in part for the hypotensive action of diazoxide. The possible r{\^o}les of water and electrolyte redistribution remain to be elucidated.",
author = "G. Leonetti and S. Grazi and A. Ligresti and S. Romano and A. Zanchetti",
year = "1970",
month = "10",
doi = "10.1007/BF00404302",
language = "English",
volume = "2",
pages = "206--215",
journal = "European Journal of Clinical Pharmacology",
issn = "0031-6970",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Autonomic and renal effects of intravenous diazoxide. A study of the mechanisms of its hypotensive action in man

AU - Leonetti, G.

AU - Grazi, S.

AU - Ligresti, A.

AU - Romano, S.

AU - Zanchetti, A.

PY - 1970/10

Y1 - 1970/10

N2 - Intravenous diazoxide produced an immediate marked hypotension in both mild and severe hypertensive patients. Depression of vasomotor reflexes, tested by the Valsalva overshoot, and of pressor responsiveness to noradrenaline was found only in the group of mild hypertensives. Decreased pressor reactivity to noradrenaline was not due to a nonspecific vascular effect of diazoxide, because pressor responsiveness to angiotensin was simultaneously increased. Renal tubular reabsorption of sodium and water was increased shortly after injection of diazoxide, and there was also a significant retention of potassium. Correlation studies suggest that interference with vasomotor reflexes, and with vascular responsiveness to the sympathetic transmitter, can account only in part for the hypotensive action of diazoxide. The possible rôles of water and electrolyte redistribution remain to be elucidated.

AB - Intravenous diazoxide produced an immediate marked hypotension in both mild and severe hypertensive patients. Depression of vasomotor reflexes, tested by the Valsalva overshoot, and of pressor responsiveness to noradrenaline was found only in the group of mild hypertensives. Decreased pressor reactivity to noradrenaline was not due to a nonspecific vascular effect of diazoxide, because pressor responsiveness to angiotensin was simultaneously increased. Renal tubular reabsorption of sodium and water was increased shortly after injection of diazoxide, and there was also a significant retention of potassium. Correlation studies suggest that interference with vasomotor reflexes, and with vascular responsiveness to the sympathetic transmitter, can account only in part for the hypotensive action of diazoxide. The possible rôles of water and electrolyte redistribution remain to be elucidated.

UR - http://www.scopus.com/inward/record.url?scp=34250486551&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250486551&partnerID=8YFLogxK

U2 - 10.1007/BF00404302

DO - 10.1007/BF00404302

M3 - Article

AN - SCOPUS:34250486551

VL - 2

SP - 206

EP - 215

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

SN - 0031-6970

IS - 4

ER -