Autonomic control of heart period in duodenal ulcer patients: Insights from spectral analysis of heart rate variability

Daniela Lucini, Manfredo Cerchiello, Guido Basilisco, Manuela Cainelli, Paolo A. Bianchi, Gemino Fiorelli, Alberto Malliani, Massimo Pagani

Research output: Contribution to journalArticle

Abstract

Beyond the fundamental pathogenetic importance of Helicobacter Pylori a possible additional role of vagal innervation in favouring or modulating the clinical history of duodenal ulcer (DU) has been suggested by old studies employing invasive methodologies. Aim of this study was to assess whether vagal prevalence in autonomic modulation was present in healed DU patients (n = 20) as compared to controls, (n = 50), using a validated non-invasive methodology, based on spectral analysisis of cardiovascular variability. This approach provides markers of the sympathetic and vagal modulations of the SA node, respectively by way of the normalized low frequency (LF(RR)) and high frequency (HF(RR)) components of RR interval variability; LF/HF ratio furnishes a marker of sympatho-vagal balance. In addition, sham feeding (SF) provided a means to assess, in DU patients, neurally mediated acid secretion, as the SF acid output (SAO) to basal acid output (BAO) ratio (SAO/BAO). Results showed that LF(RR) was smaller in DU patients than in controls (40.3 ± 3.9 vs. 52.3 ± 2.3 normalized units, nu; P <0.05). On the contrary, HF(RR) was greater (52.1 ± 3.7 vs. 35.7 ± 2.3 nu; P <0.05). Conversely the LF component of SAP variability, a marker of sympathetic vasomotor modulations, and the index α, a measure of baroreflex control of the SA node, as well as respiratory patterns, were similar in the two groups. SAO/BAO ratio was significantly correlated with markers of autonomic control of the SA node (r = -0.67, P <0.0083 with HF(RR)). In conclusion results suggest an enhanced vagal modulation of heart period in DU patients at rest, that appears linked to indices of neurally mediated gastric acid secretion response. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)122-129
Number of pages8
JournalAutonomic Neuroscience: Basic and Clinical
Volume84
Issue number3
DOIs
Publication statusPublished - Nov 1 2000

Keywords

  • Heart rate variability
  • Spectral analysis
  • Sympatho-vagal balance

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems

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