Abstract
Objectives Although it is well documented that an exaggerated sympathetic stimulation plays a role in the development of Takotsubo Syndrome (TS) during the acute phase, only few studies have focused on autonomic adaptations in stress-induced cardiomyopathy long after the acute phase. Aim of the study was to investigate whether an impairment of the autonomic function is still present long after a TS event. This was done by comparing the response to a maximal exercise test in TS patients after apparent recovery (> 1-year after the acute event) with that obtained in healthy subjects and in post-myocardial infarction (post-MI) patients. Methods To assess heart rate recovery (HRR) and chronotropic response (CR), 24 TS patients, 25 healthy subjects and 22 post-MI patients underwent maximal exercise test, after at least 3 days of β-blockers wash-out. Results HRR in TS patients (19.2 ± 9.7 bpm) was lower than in healthy subjects (27.7 ± 8.3, p = 0.003), and similar to post-MI patients (19.3 ± 8.4; p = 0.99). A decreasing CR trend (p=0.06), higher in healthy subjects (72±13%) than in TS (65±22%) and post-MI (57±21%) patients, was also found. Conclusion Compared to healthy subjects, TS patients showed a blunted parasympathetic reactivation after exercise, similar to that observed in post-MI patients, thereby suggesting that vagal control of heart rate after exercise is abnormal long after the acute presentation of TS.
| Original language | English |
|---|---|
| Pages (from-to) | 222-224 |
| Number of pages | 3 |
| Journal | International Journal of Cardiology |
| Volume | 231 |
| DOIs | |
| Publication status | Published - Mar 15 2017 |
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Keywords
- Autonomic nervous system
- Exercise stress test
- Heart rate recovery
- Myocardial infarction
- Takotsubo syndrome
ASJC Scopus subject areas
- Medicine(all)
- Cardiology and Cardiovascular Medicine
Cite this
Autonomic function in Takotsubo syndrome long after the acute phase. / Lazzeroni, Davide; Bini, Matteo; Castiglioni, Paolo; Moderato, Luca; Ciraci, Chiara; Camaiora, Umberto; Ugolotti, Pietro Tito; Brambilla, Lorenzo; Brambilla, Valerio; Castrichini, Matteo; Ugo, Fabrizio; Gaibazzi, Nicola; Coruzzi, Paolo.
In: International Journal of Cardiology, Vol. 231, 15.03.2017, p. 222-224.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Autonomic function in Takotsubo syndrome long after the acute phase
AU - Lazzeroni, Davide
AU - Bini, Matteo
AU - Castiglioni, Paolo
AU - Moderato, Luca
AU - Ciraci, Chiara
AU - Camaiora, Umberto
AU - Ugolotti, Pietro Tito
AU - Brambilla, Lorenzo
AU - Brambilla, Valerio
AU - Castrichini, Matteo
AU - Ugo, Fabrizio
AU - Gaibazzi, Nicola
AU - Coruzzi, Paolo
PY - 2017/3/15
Y1 - 2017/3/15
N2 - Objectives Although it is well documented that an exaggerated sympathetic stimulation plays a role in the development of Takotsubo Syndrome (TS) during the acute phase, only few studies have focused on autonomic adaptations in stress-induced cardiomyopathy long after the acute phase. Aim of the study was to investigate whether an impairment of the autonomic function is still present long after a TS event. This was done by comparing the response to a maximal exercise test in TS patients after apparent recovery (> 1-year after the acute event) with that obtained in healthy subjects and in post-myocardial infarction (post-MI) patients. Methods To assess heart rate recovery (HRR) and chronotropic response (CR), 24 TS patients, 25 healthy subjects and 22 post-MI patients underwent maximal exercise test, after at least 3 days of β-blockers wash-out. Results HRR in TS patients (19.2 ± 9.7 bpm) was lower than in healthy subjects (27.7 ± 8.3, p = 0.003), and similar to post-MI patients (19.3 ± 8.4; p = 0.99). A decreasing CR trend (p=0.06), higher in healthy subjects (72±13%) than in TS (65±22%) and post-MI (57±21%) patients, was also found. Conclusion Compared to healthy subjects, TS patients showed a blunted parasympathetic reactivation after exercise, similar to that observed in post-MI patients, thereby suggesting that vagal control of heart rate after exercise is abnormal long after the acute presentation of TS.
AB - Objectives Although it is well documented that an exaggerated sympathetic stimulation plays a role in the development of Takotsubo Syndrome (TS) during the acute phase, only few studies have focused on autonomic adaptations in stress-induced cardiomyopathy long after the acute phase. Aim of the study was to investigate whether an impairment of the autonomic function is still present long after a TS event. This was done by comparing the response to a maximal exercise test in TS patients after apparent recovery (> 1-year after the acute event) with that obtained in healthy subjects and in post-myocardial infarction (post-MI) patients. Methods To assess heart rate recovery (HRR) and chronotropic response (CR), 24 TS patients, 25 healthy subjects and 22 post-MI patients underwent maximal exercise test, after at least 3 days of β-blockers wash-out. Results HRR in TS patients (19.2 ± 9.7 bpm) was lower than in healthy subjects (27.7 ± 8.3, p = 0.003), and similar to post-MI patients (19.3 ± 8.4; p = 0.99). A decreasing CR trend (p=0.06), higher in healthy subjects (72±13%) than in TS (65±22%) and post-MI (57±21%) patients, was also found. Conclusion Compared to healthy subjects, TS patients showed a blunted parasympathetic reactivation after exercise, similar to that observed in post-MI patients, thereby suggesting that vagal control of heart rate after exercise is abnormal long after the acute presentation of TS.
KW - Autonomic nervous system
KW - Exercise stress test
KW - Heart rate recovery
KW - Myocardial infarction
KW - Takotsubo syndrome
UR - http://www.scopus.com/inward/record.url?scp=85009433853&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009433853&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2017.01.002
DO - 10.1016/j.ijcard.2017.01.002
M3 - Article
AN - SCOPUS:85009433853
VL - 231
SP - 222
EP - 224
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -