Autonomic tone changes during isometric exercise. A noninvasive study in normal subjects and in hypertensive patients

L. De Caprio, M. Papa, D. Acanfora, C. Vigorito, V. Canonico, P. Abete, S. Cuomo, F. Gallucci, F. Rengo

Research output: Contribution to journalArticle

Abstract

The influences of age and hypertension on electrical/electromechanical systole ratio (QT/QS2) changes induced by isometric exercise (75% of maximal voluntary contraction) were studied. The study population was divided into four groups: group 1 - 15 healthy subjects aged <60 years; group 2 - 10 healthy subjects aged ≥ 60 years; group 3 - 14 hypertensive patients aged <60 years, and group 4 - 17 hypertensive patients aged ≥ 60 years. Ten normal subjects and 10 hypertensive patients repeated the test after beta-blockade was induced acutely and chronically, respectively. Heart rate and blood pressure changes did not distinguish normal subjects from age-matched hypertensive patients. QT/QS2 significantly increased only in group 1 subjects. Acute propranolol administration prevented ratio increase in normal subjects; after chronic treatment with beta-blocking agents, handgrip induced a significant decrease in QT/QS2 values in hypertensive patients. QT/QS2 changes induced by isometric exercise are affected both by age and hypertension, both of which cause a reduced beta-adrenergic sensitivity.

Original languageEnglish
Pages (from-to)58-63
Number of pages6
JournalAmerican Journal of Noninvasive Cardiology
Volume3
Issue number1
Publication statusPublished - 1989

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Exercise
Healthy Volunteers
Hypertension
Systole
Propranolol
Adrenergic Agents
Heart Rate
Blood Pressure
Population
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

De Caprio, L., Papa, M., Acanfora, D., Vigorito, C., Canonico, V., Abete, P., ... Rengo, F. (1989). Autonomic tone changes during isometric exercise. A noninvasive study in normal subjects and in hypertensive patients. American Journal of Noninvasive Cardiology, 3(1), 58-63.

Autonomic tone changes during isometric exercise. A noninvasive study in normal subjects and in hypertensive patients. / De Caprio, L.; Papa, M.; Acanfora, D.; Vigorito, C.; Canonico, V.; Abete, P.; Cuomo, S.; Gallucci, F.; Rengo, F.

In: American Journal of Noninvasive Cardiology, Vol. 3, No. 1, 1989, p. 58-63.

Research output: Contribution to journalArticle

De Caprio, L, Papa, M, Acanfora, D, Vigorito, C, Canonico, V, Abete, P, Cuomo, S, Gallucci, F & Rengo, F 1989, 'Autonomic tone changes during isometric exercise. A noninvasive study in normal subjects and in hypertensive patients', American Journal of Noninvasive Cardiology, vol. 3, no. 1, pp. 58-63.
De Caprio, L. ; Papa, M. ; Acanfora, D. ; Vigorito, C. ; Canonico, V. ; Abete, P. ; Cuomo, S. ; Gallucci, F. ; Rengo, F. / Autonomic tone changes during isometric exercise. A noninvasive study in normal subjects and in hypertensive patients. In: American Journal of Noninvasive Cardiology. 1989 ; Vol. 3, No. 1. pp. 58-63.
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