Autophagic Gene Polymorphisms in Liquid Biopsies and Outcome of Patients with Metastatic Clear Cell Renal Cell Carcinoma

Matteo Santoni, Francesco Piva, Ugo DE Giorgi, Alessandra Mosca, Umberto Basso, Daniele Santini, Sebastiano Buti, Cristian Lolli, Carlo Terrone, Marco Maruzzo, Michele Iuliani, Melissa Bersanelli, Alessandro Conti, Roberta Mazzucchelli, Rodolfo Montironi, Luciano Burattini, Rossana Berardi

Research output: Contribution to journalArticle

Abstract

BACKGROUND/AIM: Autophagy has been shown to be involved in cancer development and response to cancer therapy. In this study, genotypes of autophagic genes were analyzed to assess their correlation with the risk of clear cell renal cell carcinoma (ccRCC) and the outcome of patients treated with pazopanib for metastatic ccRCC.

MATERIALS AND METHODS: Single nucleotide polymorphisms (SNPs)were selected in the following genes: ATG4A (rs7880351), ATG4B (rs6709768), ATG4C (rs2886770, rs6670694, rs6683832), ATG5 (rs9373839, rs3804333, rs490010), ATG16L1 (rs6752107), ATG16L2 (rs10751215) and IRGM (rs10059011). The Kaplan-Meier method and log-rank test were used to evaluate differences between groups.

RESULTS: Forty patients with metastatic ccRCC treated with pazopanib were included in the analysis. ATG16L2rs10751215 was significantly less frequent in patients with ccRCC compared to the general population, suggesting its potential protective role, while ATG4Ars7880351, ATG4C rs6670694 and rs6683832 and ATG5 rs490010 were correlated with the progression-free survival (PFS) of patients treated with pazopanib.

CONCLUSION: Our results suggest, for the first time, that autophagic gene SNPs are associated with ccRCC risk and patient outcome.

Original languageEnglish
Pages (from-to)5773-5782
Number of pages10
JournalAnticancer Research
Volume38
Issue number10
DOIs
Publication statusPublished - Oct 1 2018

Keywords

  • Autophagy
  • pazopanib
  • prognosis
  • progression-free survival
  • renal cell carcinoma
  • single nucleotide polymorphisms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Santoni, M., Piva, F., DE Giorgi, U., Mosca, A., Basso, U., Santini, D., Buti, S., Lolli, C., Terrone, C., Maruzzo, M., Iuliani, M., Bersanelli, M., Conti, A., Mazzucchelli, R., Montironi, R., Burattini, L., & Berardi, R. (2018). Autophagic Gene Polymorphisms in Liquid Biopsies and Outcome of Patients with Metastatic Clear Cell Renal Cell Carcinoma. Anticancer Research, 38(10), 5773-5782. https://doi.org/10.21873/anticanres.12916