Autophagy, a new determinant of plasma cell differentiation and antibody responses

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma cells, the terminal effectors of the B lymphoid lineage, are responsible for the humoral arm of adaptive immunity. Their differentiation from B cells entails a profound cellular reshaping inherently associated with stress. Autophagy is a conserved adaptive cellular strategy recently implicated in differentiation and immunity. We identified a novel autophagic function in plasma cells. Autophagy restricts the expression of the transcriptional repressor Blimp-1 and immunoglobulins through a selective negative control on the endoplasmic reticulum and its stress signaling response, thereby optimizing energy and viability. As a result, autophagy in vivo sustains antibody responses, and is an essential intrinsic determinant of the bone marrow long-lived plasma cell niche. Here, I discuss several immune and biomedical implications, and experimental issues to be addressed in the near future.

Original languageEnglish
Pages (from-to)289-295
Number of pages7
JournalMolecular Immunology
Volume62
Issue number2
DOIs
Publication statusPublished - Dec 1 2014

Keywords

  • Antibody
  • Atg5
  • Autophagy
  • B cell
  • Blimp-1
  • Endoplasmic reticulum
  • ER-phagy
  • Immunological memory
  • Multiple myeloma
  • Plasma cell
  • Proteostasis
  • Reticulophagy
  • Ubiquitin
  • Unfolded protein response
  • XBP-1

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

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