Autophagy activation in glutamate-induced motor neuron loss

F. Fulceri, M. Ferrucci, G. Lazzeri, S. Paparelli, A. Bartalucci, I. Tamburini, A. Paparelli, F. Fornai

Research output: Contribution to journalArticle

Abstract

Recent literature demonstrated that exposure to excitatory amino acid in specific experimental conditions might produce a defect in the autophagy pathway. Such an effect was observed in motor neurons exposed chronically to glutamate agonists. On the other hand, it is well known that glutamate induces motor neuron death and this is supposed to play a key role in the physiopathology of motor neuron loss in amyotrophic lateral sclerosis (ALS). Similarly, a defective recruitment of autophagy was recently documented in ALS. In the present study we found that exposure of motor neurons to kainic acid produces intracellular changes associated with defective autophagy. In this experimental conditions, pharmacological activation of autophagy rescues the loss of motor neurons.

Original languageEnglish
Pages (from-to)101-111
Number of pages11
JournalArchives Italiennes de Biologie
Volume149
Issue number1
Publication statusPublished - 2011

Keywords

  • Amyotrophic lateral sclerosis
  • Excitotoxicity
  • Kainic acid
  • Lithium
  • Motor neuron

ASJC Scopus subject areas

  • Medicine(all)
  • Cell Biology
  • Physiology

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  • Cite this

    Fulceri, F., Ferrucci, M., Lazzeri, G., Paparelli, S., Bartalucci, A., Tamburini, I., Paparelli, A., & Fornai, F. (2011). Autophagy activation in glutamate-induced motor neuron loss. Archives Italiennes de Biologie, 149(1), 101-111.