Autophagy as a pathogenic mechanism and drug target in lymphoproliferative disorders

Marina Pierdominici, Cristiana Marta Vomero Barbati, Silvia L. Locatelli, Carmelo Carlo-Stella, Elena Ortona, Walter Malorni

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Autophagy represents a key mechanism of cytoprotection that can be activated by a variety of extracellular and intracellular stresses and allows the cell to sequester cytoplasmic components and damaged organelles, delivering them to lysosomes for degradation and recycling. However, the autophagy process has also been associated with the death of the cell. It has been demonstrated to be constitutive in some instances and inducible in others, and the idea that it could represent a pathogenetic determinant as well as a possible prognostic tool and a therapeutic target in a plethora of human diseases has recently been considered. Among these, cancer represents a major one. In this review, we recapitulate the critical implications of autophagy in the pathogenesis, progression, and treatment of lymphoproliferative disorders. Leukemias and lymphomas, in fact, represent paradigmatic human diseases in which advances have recently been made in this respect.

Original languageEnglish
Pages (from-to)524-535
Number of pages12
JournalFASEB Journal
Volume28
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint

Lymphoproliferative Disorders
Autophagy
Pharmaceutical Preparations
Recycling
Cytoprotection
Cells
Lysosomes
Degradation
Organelles
Lymphoma
Leukemia
Cell Death
Neoplasms
Therapeutics

Keywords

  • Cancer
  • Cell fate
  • Hodgkin's lymphoma
  • Lymphocytes
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Biochemistry
  • Biotechnology
  • Genetics
  • Molecular Biology
  • Medicine(all)

Cite this

Pierdominici, M., Barbati, C. M. V., Locatelli, S. L., Carlo-Stella, C., Ortona, E., & Malorni, W. (2014). Autophagy as a pathogenic mechanism and drug target in lymphoproliferative disorders. FASEB Journal, 28(2), 524-535. https://doi.org/10.1096/fj.13-235655

Autophagy as a pathogenic mechanism and drug target in lymphoproliferative disorders. / Pierdominici, Marina; Barbati, Cristiana Marta Vomero; Locatelli, Silvia L.; Carlo-Stella, Carmelo; Ortona, Elena; Malorni, Walter.

In: FASEB Journal, Vol. 28, No. 2, 2014, p. 524-535.

Research output: Contribution to journalArticle

Pierdominici, M, Barbati, CMV, Locatelli, SL, Carlo-Stella, C, Ortona, E & Malorni, W 2014, 'Autophagy as a pathogenic mechanism and drug target in lymphoproliferative disorders', FASEB Journal, vol. 28, no. 2, pp. 524-535. https://doi.org/10.1096/fj.13-235655
Pierdominici, Marina ; Barbati, Cristiana Marta Vomero ; Locatelli, Silvia L. ; Carlo-Stella, Carmelo ; Ortona, Elena ; Malorni, Walter. / Autophagy as a pathogenic mechanism and drug target in lymphoproliferative disorders. In: FASEB Journal. 2014 ; Vol. 28, No. 2. pp. 524-535.
@article{8a6d0df300e045ee87548275654053c0,
title = "Autophagy as a pathogenic mechanism and drug target in lymphoproliferative disorders",
abstract = "Autophagy represents a key mechanism of cytoprotection that can be activated by a variety of extracellular and intracellular stresses and allows the cell to sequester cytoplasmic components and damaged organelles, delivering them to lysosomes for degradation and recycling. However, the autophagy process has also been associated with the death of the cell. It has been demonstrated to be constitutive in some instances and inducible in others, and the idea that it could represent a pathogenetic determinant as well as a possible prognostic tool and a therapeutic target in a plethora of human diseases has recently been considered. Among these, cancer represents a major one. In this review, we recapitulate the critical implications of autophagy in the pathogenesis, progression, and treatment of lymphoproliferative disorders. Leukemias and lymphomas, in fact, represent paradigmatic human diseases in which advances have recently been made in this respect.",
keywords = "Cancer, Cell fate, Hodgkin's lymphoma, Lymphocytes, Non-Hodgkin's lymphoma",
author = "Marina Pierdominici and Barbati, {Cristiana Marta Vomero} and Locatelli, {Silvia L.} and Carmelo Carlo-Stella and Elena Ortona and Walter Malorni",
year = "2014",
doi = "10.1096/fj.13-235655",
language = "English",
volume = "28",
pages = "524--535",
journal = "FASEB Journal",
issn = "0892-6638",
publisher = "FASEB",
number = "2",

}

TY - JOUR

T1 - Autophagy as a pathogenic mechanism and drug target in lymphoproliferative disorders

AU - Pierdominici, Marina

AU - Barbati, Cristiana Marta Vomero

AU - Locatelli, Silvia L.

AU - Carlo-Stella, Carmelo

AU - Ortona, Elena

AU - Malorni, Walter

PY - 2014

Y1 - 2014

N2 - Autophagy represents a key mechanism of cytoprotection that can be activated by a variety of extracellular and intracellular stresses and allows the cell to sequester cytoplasmic components and damaged organelles, delivering them to lysosomes for degradation and recycling. However, the autophagy process has also been associated with the death of the cell. It has been demonstrated to be constitutive in some instances and inducible in others, and the idea that it could represent a pathogenetic determinant as well as a possible prognostic tool and a therapeutic target in a plethora of human diseases has recently been considered. Among these, cancer represents a major one. In this review, we recapitulate the critical implications of autophagy in the pathogenesis, progression, and treatment of lymphoproliferative disorders. Leukemias and lymphomas, in fact, represent paradigmatic human diseases in which advances have recently been made in this respect.

AB - Autophagy represents a key mechanism of cytoprotection that can be activated by a variety of extracellular and intracellular stresses and allows the cell to sequester cytoplasmic components and damaged organelles, delivering them to lysosomes for degradation and recycling. However, the autophagy process has also been associated with the death of the cell. It has been demonstrated to be constitutive in some instances and inducible in others, and the idea that it could represent a pathogenetic determinant as well as a possible prognostic tool and a therapeutic target in a plethora of human diseases has recently been considered. Among these, cancer represents a major one. In this review, we recapitulate the critical implications of autophagy in the pathogenesis, progression, and treatment of lymphoproliferative disorders. Leukemias and lymphomas, in fact, represent paradigmatic human diseases in which advances have recently been made in this respect.

KW - Cancer

KW - Cell fate

KW - Hodgkin's lymphoma

KW - Lymphocytes

KW - Non-Hodgkin's lymphoma

UR - http://www.scopus.com/inward/record.url?scp=84897105743&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897105743&partnerID=8YFLogxK

U2 - 10.1096/fj.13-235655

DO - 10.1096/fj.13-235655

M3 - Article

C2 - 24196588

AN - SCOPUS:84897105743

VL - 28

SP - 524

EP - 535

JO - FASEB Journal

JF - FASEB Journal

SN - 0892-6638

IS - 2

ER -