Autophagy as a pathogenic mechanism and drug target in lymphoproliferative disorders

Marina Pierdominici, Cristiana Marta Vomero Barbati, Silvia L. Locatelli, Carmelo Carlo-Stella, Elena Ortona, Walter Malorni

Research output: Contribution to journalArticlepeer-review

Abstract

Autophagy represents a key mechanism of cytoprotection that can be activated by a variety of extracellular and intracellular stresses and allows the cell to sequester cytoplasmic components and damaged organelles, delivering them to lysosomes for degradation and recycling. However, the autophagy process has also been associated with the death of the cell. It has been demonstrated to be constitutive in some instances and inducible in others, and the idea that it could represent a pathogenetic determinant as well as a possible prognostic tool and a therapeutic target in a plethora of human diseases has recently been considered. Among these, cancer represents a major one. In this review, we recapitulate the critical implications of autophagy in the pathogenesis, progression, and treatment of lymphoproliferative disorders. Leukemias and lymphomas, in fact, represent paradigmatic human diseases in which advances have recently been made in this respect.

Original languageEnglish
Pages (from-to)524-535
Number of pages12
JournalFASEB Journal
Volume28
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • Cancer
  • Cell fate
  • Hodgkin's lymphoma
  • Lymphocytes
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Biochemistry
  • Biotechnology
  • Genetics
  • Molecular Biology
  • Medicine(all)

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