Autophagy in blood cancers: Biological role and therapeutic implications

Alessio Nencioni, Michele Cea, Fabrizio Montecucco, Valter D. Longo, Franco Patrone, Angelo M. Carella, Tessa L. Holyoake, G. Vignir Helgason

Research output: Contribution to journalArticle

Abstract

Autophagy is a cell recycling process the molecular apparatus of which has been identified over the past decade. Autophagy allows cells to survive starvation and inhospitable conditions and plays a key role in numerous physiological functions, including hematopoiesis and immune responses. In hematologic malignancies, autophagy can either act as a chemo-resistance mechanism or have tumor suppressive functions, depending on the context. In addition, autophagy is involved in other important aspects of blood cancers as it promotes immune competence and anticancer immunity, and may even help enhance patient tolerance to standard treatments. Approaches exploiting autophagy, either to activate or inhibit it, could find broad application in hematologic malignancies and contribute to improved clinical outcomes. These aspects are discussed here together with a brief introduction to the molecular machinery of autophagy and to its role in blood cell physiology.

Original languageEnglish
Pages (from-to)1335-1343
Number of pages9
JournalHaematologica
Volume98
Issue number9
DOIs
Publication statusPublished - Sep 1 2013

ASJC Scopus subject areas

  • Hematology

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    Nencioni, A., Cea, M., Montecucco, F., Longo, V. D., Patrone, F., Carella, A. M., Holyoake, T. L., & Vignir Helgason, G. (2013). Autophagy in blood cancers: Biological role and therapeutic implications. Haematologica, 98(9), 1335-1343. https://doi.org/10.3324/haematol.2012.079061